Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease

Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease

Summary: Despite intuitive insights into differential proteolysis of amyloid precursor protein (APP), the stochasticity behind local product formation through amyloidogenic pathway at individual synapses remain unclear. Here, we show that the major components of amyloidogenic machinery namely, APP a...

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Bibliographic Details
Main Authors: Shekhar Kedia, Pratyush Ramakrishna, Pallavi Rao Netrakanti, Nivedita Singh, Sangram S. Sisodia, Mini Jose, Sathish Kumar, Anita Mahadevan, Narendrakumar Ramanan, Suhita Nadkarni, Deepak Nair
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Cellular Neuroscience
Molecular Neuroscience
Optical Imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220311214

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