Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma
Abstract Background Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC. Results We h...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Biological Research |
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| Online Access: | http://link.springer.com/article/10.1186/s40659-017-0142-7 |
| _version_ | 1818525821300637696 |
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| author | Haijie Xing Xiangdong Chen Yaofeng Han |
| author_facet | Haijie Xing Xiangdong Chen Yaofeng Han |
| author_sort | Haijie Xing |
| collection | DOAJ |
| description | Abstract Background Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC. Results We have found that there was 63 patients with REGIA positive expression of 155 patients in this study (40.65%). The positive expression rate of REGIA was 30.50, 44.44 and 47.83% in stage T2, T3 and T4 patients, respectively. The REGIA expression was significantly difference in T2 and T4 stage tumors or T2 and T3–T4 stage. The positive expression rate of REGIA was found to be higher in patients with cervical lymph node persistence than those with cervical lymph node complete regression. Patients with negative REGIA expression had a better overall survival and free survival than those with REGIA positive expression. In addition, according to the univariate and multivariate analysis, the REGIA expression was an independent adverse prognostic factor for NPC patients. Conclusion REGIA expression was a useful biomarker in NPC patients for assessing T stage and survival. |
| first_indexed | 2024-12-11T06:14:28Z |
| format | Article |
| id | doaj.art-21ea546ef45d4b57b057075f52b8e7ba |
| institution | Directory Open Access Journal |
| issn | 0717-6287 |
| language | English |
| last_indexed | 2024-12-11T06:14:28Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-21ea546ef45d4b57b057075f52b8e7ba2022-12-22T01:18:02ZengBMCBiological Research0717-62872017-11-015011710.1186/s40659-017-0142-7S0716-97602017000100227Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinomaHaijie Xing0Xiangdong Chen1Yaofeng Han2Department of Otorhinolaryngology Head and Neck Surgery, Guang Ming New District People’s HospitalDepartment of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Shenzhen UniversityDepartment of Epidemiology, Public Health College of Xiamen UniversityAbstract Background Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC. Results We have found that there was 63 patients with REGIA positive expression of 155 patients in this study (40.65%). The positive expression rate of REGIA was 30.50, 44.44 and 47.83% in stage T2, T3 and T4 patients, respectively. The REGIA expression was significantly difference in T2 and T4 stage tumors or T2 and T3–T4 stage. The positive expression rate of REGIA was found to be higher in patients with cervical lymph node persistence than those with cervical lymph node complete regression. Patients with negative REGIA expression had a better overall survival and free survival than those with REGIA positive expression. In addition, according to the univariate and multivariate analysis, the REGIA expression was an independent adverse prognostic factor for NPC patients. Conclusion REGIA expression was a useful biomarker in NPC patients for assessing T stage and survival.http://link.springer.com/article/10.1186/s40659-017-0142-7Nasopharyngeal carcinomaRegenerating gene IAInvasionSurvival |
| spellingShingle | Haijie Xing Xiangdong Chen Yaofeng Han Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma Biological Research Nasopharyngeal carcinoma Regenerating gene IA Invasion Survival |
| title | Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma |
| title_full | Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma |
| title_fullStr | Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma |
| title_full_unstemmed | Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma |
| title_short | Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma |
| title_sort | role of regenerating gene ia expression on local invasion and survival in nasopharyngeal carcinoma |
| topic | Nasopharyngeal carcinoma Regenerating gene IA Invasion Survival |
| url | http://link.springer.com/article/10.1186/s40659-017-0142-7 |
| work_keys_str_mv | AT haijiexing roleofregeneratinggeneiaexpressiononlocalinvasionandsurvivalinnasopharyngealcarcinoma AT xiangdongchen roleofregeneratinggeneiaexpressiononlocalinvasionandsurvivalinnasopharyngealcarcinoma AT yaofenghan roleofregeneratinggeneiaexpressiononlocalinvasionandsurvivalinnasopharyngealcarcinoma |