Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
During Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22442-3 |
| _version_ | 1828958848190251008 |
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| author | Miaoxing Wang Xujun Han Chuyan Liu Rie Takayama Tetsuo Yasugi Shin-Ichiro Ei Masaharu Nagayama Yoshitaro Tanaka Makoto Sato |
| author_facet | Miaoxing Wang Xujun Han Chuyan Liu Rie Takayama Tetsuo Yasugi Shin-Ichiro Ei Masaharu Nagayama Yoshitaro Tanaka Makoto Sato |
| author_sort | Miaoxing Wang |
| collection | DOAJ |
| description | During Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain. |
| first_indexed | 2024-12-14T08:55:15Z |
| format | Article |
| id | doaj.art-21ea5b007b2e48b5a7e21e0a8c15e3d0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:55:15Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-21ea5b007b2e48b5a7e21e0a8c15e3d02022-12-21T23:08:56ZengNature PortfolioNature Communications2041-17232021-04-0112111510.1038/s41467-021-22442-3Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brainMiaoxing Wang0Xujun Han1Chuyan Liu2Rie Takayama3Tetsuo Yasugi4Shin-Ichiro Ei5Masaharu Nagayama6Yoshitaro Tanaka7Makoto Sato8Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityMathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityLaboratory of Developmental Neurobiology, Graduate School of Medical Sciences, Kanazawa UniversityMathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityMathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityDepartment of Mathematics, Faculty of Science, Hokkaido UniversityResearch Institute for Electronic Science, Research Center of Mathematics for Social Creativity, Hokkaido UniversityDepartment of Complex and Intelligent Systems, School of Systems Information Science, Future University HakodateMathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityDuring Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.https://doi.org/10.1038/s41467-021-22442-3 |
| spellingShingle | Miaoxing Wang Xujun Han Chuyan Liu Rie Takayama Tetsuo Yasugi Shin-Ichiro Ei Masaharu Nagayama Yoshitaro Tanaka Makoto Sato Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain Nature Communications |
| title | Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain |
| title_full | Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain |
| title_fullStr | Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain |
| title_full_unstemmed | Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain |
| title_short | Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain |
| title_sort | intracellular trafficking of notch orchestrates temporal dynamics of notch activity in the fly brain |
| url | https://doi.org/10.1038/s41467-021-22442-3 |
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