Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism status
Abstract Background The Triglyceride glucose-body mass index (TyG-BMI) and hemoglobin glycation index (HGI) are well-established surrogate markers for insulin resistance. Nevertheless, the extent to which these markers offer additive predictive value for heart failure (HF) prevalence in hypertensive...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-024-02045-9 |
| _version_ | 1827326364290646016 |
|---|---|
| author | Rupeng Wang Ce Chen Guiyu Xu Zening Jin |
| author_facet | Rupeng Wang Ce Chen Guiyu Xu Zening Jin |
| author_sort | Rupeng Wang |
| collection | DOAJ |
| description | Abstract Background The Triglyceride glucose-body mass index (TyG-BMI) and hemoglobin glycation index (HGI) are well-established surrogate markers for insulin resistance. Nevertheless, the extent to which these markers offer additive predictive value for heart failure (HF) prevalence in hypertensive populations, and their predictive utility across various diabetic statuses, remains to be clarified. Consequently, this study aimed to explore the independent and synergistic effects of TyG-BMI and HGI on HF risk among individuals with different diabetic statuses. Methods Data from the study population (n = 9847) were obtained from the National Health and Nutrition Examination Survey (NHANES). Multivariable logistic regression models were employed to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the combined associations between TyG-BMI and HGI and the prevalence of HF across various diabetic statuses. Results In the total population, compared to the reference group (low TyG-BMI and low HGI), the OR (95% CI) for HF prevalence was 1.30 (1.04, 1.64) for the combination of low TyG-BMI and high HGI, 2.40 (1.76, 3.29) for high TyG-BMI and low HGI, and 3.47 (2.41, 4.99) for high TyG-BMI and high HGI. Interestingly, among normoglycemic individuals, higher TyG-BMI and HGI did not significantly increase the prevalence of HF. Conversely, in the prediabetic population, the OR (95%CI) for HF prevalence was 2.42 (1.69, 3.48) for the combination of high TyG-BMI and low HGI, and 4.30 (2.45, 7.54) for high TyG-BMI and high HGI. Similarly, in the diabetic population, the OR (95%CI) for HF prevalence was 2.22 (1.43, 3.45) for low TyG-BMI and high HGI, 4.04 (2.43, 6.73) for high TyG-BMI and low HGI, and 4.13 (2.25, 7.59) for high TyG-BMI and high HGI, compared to low TyG-BMI and low HGI. Conclusion This study reveals that elevated TyG-BMI and HGI levels exert a synergistic impact on the prevalence of HF in hypertensive adults, especially in those with prediabetes and diabetes. Additionally, the presence of prediabetes and diabetes may amplify the detrimental combined effect of TyG-BMI and HGI on HF prevalence. |
| first_indexed | 2024-03-07T14:43:23Z |
| format | Article |
| id | doaj.art-21ebb0d3348447c1b89a7b2e83a3cd9b |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-07T14:43:23Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-21ebb0d3348447c1b89a7b2e83a3cd9b2024-03-05T20:08:00ZengBMCLipids in Health and Disease1476-511X2024-02-0123111210.1186/s12944-024-02045-9Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism statusRupeng Wang0Ce Chen1Guiyu Xu2Zening Jin3Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background The Triglyceride glucose-body mass index (TyG-BMI) and hemoglobin glycation index (HGI) are well-established surrogate markers for insulin resistance. Nevertheless, the extent to which these markers offer additive predictive value for heart failure (HF) prevalence in hypertensive populations, and their predictive utility across various diabetic statuses, remains to be clarified. Consequently, this study aimed to explore the independent and synergistic effects of TyG-BMI and HGI on HF risk among individuals with different diabetic statuses. Methods Data from the study population (n = 9847) were obtained from the National Health and Nutrition Examination Survey (NHANES). Multivariable logistic regression models were employed to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the combined associations between TyG-BMI and HGI and the prevalence of HF across various diabetic statuses. Results In the total population, compared to the reference group (low TyG-BMI and low HGI), the OR (95% CI) for HF prevalence was 1.30 (1.04, 1.64) for the combination of low TyG-BMI and high HGI, 2.40 (1.76, 3.29) for high TyG-BMI and low HGI, and 3.47 (2.41, 4.99) for high TyG-BMI and high HGI. Interestingly, among normoglycemic individuals, higher TyG-BMI and HGI did not significantly increase the prevalence of HF. Conversely, in the prediabetic population, the OR (95%CI) for HF prevalence was 2.42 (1.69, 3.48) for the combination of high TyG-BMI and low HGI, and 4.30 (2.45, 7.54) for high TyG-BMI and high HGI. Similarly, in the diabetic population, the OR (95%CI) for HF prevalence was 2.22 (1.43, 3.45) for low TyG-BMI and high HGI, 4.04 (2.43, 6.73) for high TyG-BMI and low HGI, and 4.13 (2.25, 7.59) for high TyG-BMI and high HGI, compared to low TyG-BMI and low HGI. Conclusion This study reveals that elevated TyG-BMI and HGI levels exert a synergistic impact on the prevalence of HF in hypertensive adults, especially in those with prediabetes and diabetes. Additionally, the presence of prediabetes and diabetes may amplify the detrimental combined effect of TyG-BMI and HGI on HF prevalence.https://doi.org/10.1186/s12944-024-02045-9Heart failureTriglyceride glucose-body mass indexHemoglobin glycation indexDiabetic statusHypertension |
| spellingShingle | Rupeng Wang Ce Chen Guiyu Xu Zening Jin Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism status Lipids in Health and Disease Heart failure Triglyceride glucose-body mass index Hemoglobin glycation index Diabetic status Hypertension |
| title | Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism status |
| title_full | Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism status |
| title_fullStr | Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism status |
| title_full_unstemmed | Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism status |
| title_short | Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism status |
| title_sort | association of triglyceride glucose body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations a study across different glucose metabolism status |
| topic | Heart failure Triglyceride glucose-body mass index Hemoglobin glycation index Diabetic status Hypertension |
| url | https://doi.org/10.1186/s12944-024-02045-9 |
| work_keys_str_mv | AT rupengwang associationoftriglycerideglucosebodymassindexandhemoglobinglycationindexwithheartfailureprevalenceinhypertensivepopulationsastudyacrossdifferentglucosemetabolismstatus AT cechen associationoftriglycerideglucosebodymassindexandhemoglobinglycationindexwithheartfailureprevalenceinhypertensivepopulationsastudyacrossdifferentglucosemetabolismstatus AT guiyuxu associationoftriglycerideglucosebodymassindexandhemoglobinglycationindexwithheartfailureprevalenceinhypertensivepopulationsastudyacrossdifferentglucosemetabolismstatus AT zeningjin associationoftriglycerideglucosebodymassindexandhemoglobinglycationindexwithheartfailureprevalenceinhypertensivepopulationsastudyacrossdifferentglucosemetabolismstatus |