Autoimmunity: Are we asking the right question?
For decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.864633/full |
| _version_ | 1828157119149375488 |
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| author | Polly Matzinger |
| author_facet | Polly Matzinger |
| author_sort | Polly Matzinger |
| collection | DOAJ |
| description | For decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology. |
| first_indexed | 2024-04-11T23:22:55Z |
| format | Article |
| id | doaj.art-21efb28d91df4dec8f8c0d0a482fc458 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T23:22:55Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-21efb28d91df4dec8f8c0d0a482fc4582022-12-22T03:57:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.864633864633Autoimmunity: Are we asking the right question?Polly MatzingerFor decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology.https://www.frontiersin.org/articles/10.3389/fimmu.2022.864633/fullautoimmunityautoreactivityT helper cells (Th cells)programmed cell death, danger modeltissue resident cellstissue-based class control |
| spellingShingle | Polly Matzinger Autoimmunity: Are we asking the right question? Frontiers in Immunology autoimmunity autoreactivity T helper cells (Th cells) programmed cell death, danger model tissue resident cells tissue-based class control |
| title | Autoimmunity: Are we asking the right question? |
| title_full | Autoimmunity: Are we asking the right question? |
| title_fullStr | Autoimmunity: Are we asking the right question? |
| title_full_unstemmed | Autoimmunity: Are we asking the right question? |
| title_short | Autoimmunity: Are we asking the right question? |
| title_sort | autoimmunity are we asking the right question |
| topic | autoimmunity autoreactivity T helper cells (Th cells) programmed cell death, danger model tissue resident cells tissue-based class control |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.864633/full |
| work_keys_str_mv | AT pollymatzinger autoimmunityareweaskingtherightquestion |