Effectiveness and Nephrotoxicity of Intravenous Polymyxin B in Chinese Patients With MDR and XDR Nosocomial Pneumonia

Effectiveness and Nephrotoxicity of Intravenous Polymyxin B in Chinese Patients With MDR and XDR Nosocomial Pneumonia

Background: Nosocomial pneumonia is a major health and economic burden globally. Multidrug-resistant (MDR) or extensively drug-resistant (XDR) Gram-negative bacteria are the most common causative pathogens in critically-ill patients. Polymyxin B is a salvage therapy for MDR Gram-negative pathogens;...

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Bibliographic Details
Main Authors: Huihui Zeng, Zihang Zeng, Xianglong Kong, Hongliang Zhang, Ping Chen, Hong Luo, Yan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
polymyxin B
effectiveness
nephrotoxicity
nosocomial pneumonia
drug-resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.579069/full

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