Enterovirus D68 Infection in Human Primary Airway and Brain Organoids: No Additional Role for Heparan Sulfate Binding for Neurotropism

Enterovirus D68 Infection in Human Primary Airway and Brain Organoids: No Additional Role for Heparan Sulfate Binding for Neurotropism

ABSTRACT Enterovirus D68 (EV-D68) is an RNA virus that can cause outbreaks of acute flaccid paralysis (AFP), a polio-like disease. Before 2010, EV-D68 was a rare pathogen associated with mild respiratory symptoms, but the recent EV-D68 related increase in severe respiratory illness and outbreaks of...

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Main Authors: Adithya Sridhar, Josse A. Depla, Lance A. Mulder, Eveliina Karelehto, Lieke Brouwer, Leonie Kruiswijk, Renata Vieira de Sá, Adam Meijer, Melvin M. Evers, Frank J. M. van Kuppeveld, Dasja Pajkrt, Katja C. Wolthers
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
receptors
cerebral organoids
enterovirus
enterovirus D68
human airway epithelial cultures (HAE)
neurotropism
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01694-22

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