Modified halloysite nanoclay as a vehicle for sustained drug delivery
This paper presents the effect of modified halloysite nanotubes on the sustained drug release mechanisms of sodium salicylate. Acid treatment and composite polymer-halloysite modification techniques were adopted in this study. After each modification, sodium salicylate drug was loaded, and in vitro...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-07-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584401830820X |
| _version_ | 1818066638369456128 |
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| author | Ernest Gyan Bediako Emmanuel Nyankson David Dodoo-Arhin Benjamin Agyei-Tuffour Dariusz Łukowiec Błażej Tomiczek Abu Yaya Johnson K. Efavi |
| author_facet | Ernest Gyan Bediako Emmanuel Nyankson David Dodoo-Arhin Benjamin Agyei-Tuffour Dariusz Łukowiec Błażej Tomiczek Abu Yaya Johnson K. Efavi |
| author_sort | Ernest Gyan Bediako |
| collection | DOAJ |
| description | This paper presents the effect of modified halloysite nanotubes on the sustained drug release mechanisms of sodium salicylate. Acid treatment and composite polymer-halloysite modification techniques were adopted in this study. After each modification, sodium salicylate drug was loaded, and in vitro release properties were evaluated and compared with the raw unmodified halloysite nanotubes. The results obtained from SEM, TEM and FTIR analyses indicate that both acid treatment and composite formation have no effect on the tubular structure and morphology of halloysite. However, modification of the halloysite nanotubes did influence the drug release rate. In the acid treatment modification, there was an improved loading of sodium salicylate drug which resulted in the sustain release of large amount of the sodium salicylate. In the polymer/halloysite composite formation, a consistent layer of polymer was formed around the halloysite during the composite formation and thus delayed release providing sustained release of sodium salicylate drug over a longer period of time as compared to the acid treated and unmodified halloysite. The results from the invitro release were best fitted with the Higuchi and the Koresymer-Peppas models. |
| first_indexed | 2024-12-10T15:10:58Z |
| format | Article |
| id | doaj.art-21f3b1decbfd4cd1a58cc92f45a1bf42 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-10T15:10:58Z |
| publishDate | 2018-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-21f3b1decbfd4cd1a58cc92f45a1bf422022-12-22T01:43:55ZengElsevierHeliyon2405-84402018-07-0147e00689Modified halloysite nanoclay as a vehicle for sustained drug deliveryErnest Gyan Bediako0Emmanuel Nyankson1David Dodoo-Arhin2Benjamin Agyei-Tuffour3Dariusz Łukowiec4Błażej Tomiczek5Abu Yaya6Johnson K. Efavi7Department of Materials Science and Engineering, University of Ghana, Legon, Accra, Ghana; Institute of Mechanical Engineering, Silesian University of Technology, Gliwice, PolandDepartment of Materials Science and Engineering, University of Ghana, Legon, Accra, Ghana; Corresponding author.Department of Materials Science and Engineering, University of Ghana, Legon, Accra, GhanaDepartment of Materials Science and Engineering, University of Ghana, Legon, Accra, GhanaInstitute of Mechanical Engineering, Silesian University of Technology, Gliwice, PolandInstitute of Mechanical Engineering, Silesian University of Technology, Gliwice, PolandDepartment of Materials Science and Engineering, University of Ghana, Legon, Accra, GhanaDepartment of Materials Science and Engineering, University of Ghana, Legon, Accra, GhanaThis paper presents the effect of modified halloysite nanotubes on the sustained drug release mechanisms of sodium salicylate. Acid treatment and composite polymer-halloysite modification techniques were adopted in this study. After each modification, sodium salicylate drug was loaded, and in vitro release properties were evaluated and compared with the raw unmodified halloysite nanotubes. The results obtained from SEM, TEM and FTIR analyses indicate that both acid treatment and composite formation have no effect on the tubular structure and morphology of halloysite. However, modification of the halloysite nanotubes did influence the drug release rate. In the acid treatment modification, there was an improved loading of sodium salicylate drug which resulted in the sustain release of large amount of the sodium salicylate. In the polymer/halloysite composite formation, a consistent layer of polymer was formed around the halloysite during the composite formation and thus delayed release providing sustained release of sodium salicylate drug over a longer period of time as compared to the acid treated and unmodified halloysite. The results from the invitro release were best fitted with the Higuchi and the Koresymer-Peppas models.http://www.sciencedirect.com/science/article/pii/S240584401830820XBiomedical engineeringMaterials scienceNanotechnology |
| spellingShingle | Ernest Gyan Bediako Emmanuel Nyankson David Dodoo-Arhin Benjamin Agyei-Tuffour Dariusz Łukowiec Błażej Tomiczek Abu Yaya Johnson K. Efavi Modified halloysite nanoclay as a vehicle for sustained drug delivery Heliyon Biomedical engineering Materials science Nanotechnology |
| title | Modified halloysite nanoclay as a vehicle for sustained drug delivery |
| title_full | Modified halloysite nanoclay as a vehicle for sustained drug delivery |
| title_fullStr | Modified halloysite nanoclay as a vehicle for sustained drug delivery |
| title_full_unstemmed | Modified halloysite nanoclay as a vehicle for sustained drug delivery |
| title_short | Modified halloysite nanoclay as a vehicle for sustained drug delivery |
| title_sort | modified halloysite nanoclay as a vehicle for sustained drug delivery |
| topic | Biomedical engineering Materials science Nanotechnology |
| url | http://www.sciencedirect.com/science/article/pii/S240584401830820X |
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