Correlation Between Wnt5a Expression and Vasculogenic Mimicry in Prostate Cancer Tissues
Objective To investigate the correlation of Wnt5a expression and vasculogenic mimicry (VM) in prostate cancer tissues, and analyze their relationships with cancer stem cells (CSCs) characteristics and epithelial–mesenchymal transition (EMT). Methods Immunohistochemistry was conducted to detect the e...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2024-01-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2024.23.0670 |
| _version_ | 1797300409606340608 |
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| author | LIU Bide LI Xun WANG Shuheng JIA Hongliang ZHANG Xiaoan LI Jiuzhi |
| author_facet | LIU Bide LI Xun WANG Shuheng JIA Hongliang ZHANG Xiaoan LI Jiuzhi |
| author_sort | LIU Bide |
| collection | DOAJ |
| description | Objective To investigate the correlation of Wnt5a expression and vasculogenic mimicry (VM) in prostate cancer tissues, and analyze their relationships with cancer stem cells (CSCs) characteristics and epithelial–mesenchymal transition (EMT). Methods Immunohistochemistry was conducted to detect the expression of Wnt5a in 50 prostate cancer tissues and 50 benign prostatic hyperplasia tissues. The expression levels of CD133, vimentin, and E-cadherin were detected in the prostate cancer tissues, and CD34/PAS double staining was used to detect VM structures. We analyzed the difference in Wnt5a level between prostate cancer and benign prostatic hyperplasia tissues, the clinical significance of Wnt5a and VM, the relationship of Wnt5a expression and VM, and the relationships of Wnt5a expression and VM with CD133, Vimentin, E-cadherin. Results The expression of Wnt5a was significantly higher in prostate cancer tissues than in benign prostatic hyperplasia (P < 0.05). A positive correlation was observed between Wnt5a expression and VM (P < 0.05). The expression levels of Wnt5a and VM were positively correlated with those of CD133 and vimentin (P < 0.05). Wnt5a expression and VM were positively correlated with Gleason score, vas deferens invasion and lymphatic metastasis (P < 0.05) of prostate cancer, and VM was also positively correlated with T stage of prostate cancer (P < 0.05). Conclusion The expression level of Wnt5a in prostate cancer tissues is elevated and positively related with VM formation. Wnt5a expression and VM are correlated with cancer stem cells characteristics and the expression of epithelial–mesenchymal transition marker proteins. |
| first_indexed | 2024-03-07T23:06:46Z |
| format | Article |
| id | doaj.art-21f3d32391c04426b1095e09da246941 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-03-07T23:06:46Z |
| publishDate | 2024-01-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-21f3d32391c04426b1095e09da2469412024-02-22T02:48:35ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782024-01-01511434810.3971/j.issn.1000-8578.2024.23.06708578.2024.23.0670Correlation Between Wnt5a Expression and Vasculogenic Mimicry in Prostate Cancer TissuesLIU Bide0LI Xun1WANG Shuheng2JIA Hongliang3ZHANG Xiaoan4LI Jiuzhi5Department of Urology, Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, ChinaDepartment of Urology, Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, ChinaDepartment of Urology, Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, ChinaDepartment of Urology, Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, ChinaDepartment of Urology, Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, ChinaDepartment of Urology, Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, ChinaObjective To investigate the correlation of Wnt5a expression and vasculogenic mimicry (VM) in prostate cancer tissues, and analyze their relationships with cancer stem cells (CSCs) characteristics and epithelial–mesenchymal transition (EMT). Methods Immunohistochemistry was conducted to detect the expression of Wnt5a in 50 prostate cancer tissues and 50 benign prostatic hyperplasia tissues. The expression levels of CD133, vimentin, and E-cadherin were detected in the prostate cancer tissues, and CD34/PAS double staining was used to detect VM structures. We analyzed the difference in Wnt5a level between prostate cancer and benign prostatic hyperplasia tissues, the clinical significance of Wnt5a and VM, the relationship of Wnt5a expression and VM, and the relationships of Wnt5a expression and VM with CD133, Vimentin, E-cadherin. Results The expression of Wnt5a was significantly higher in prostate cancer tissues than in benign prostatic hyperplasia (P < 0.05). A positive correlation was observed between Wnt5a expression and VM (P < 0.05). The expression levels of Wnt5a and VM were positively correlated with those of CD133 and vimentin (P < 0.05). Wnt5a expression and VM were positively correlated with Gleason score, vas deferens invasion and lymphatic metastasis (P < 0.05) of prostate cancer, and VM was also positively correlated with T stage of prostate cancer (P < 0.05). Conclusion The expression level of Wnt5a in prostate cancer tissues is elevated and positively related with VM formation. Wnt5a expression and VM are correlated with cancer stem cells characteristics and the expression of epithelial–mesenchymal transition marker proteins.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2024.23.0670prostate cancerwnt5avasculogenic mimicrycancer stem cellepithelial-mesenchymal transition |
| spellingShingle | LIU Bide LI Xun WANG Shuheng JIA Hongliang ZHANG Xiaoan LI Jiuzhi Correlation Between Wnt5a Expression and Vasculogenic Mimicry in Prostate Cancer Tissues Zhongliu Fangzhi Yanjiu prostate cancer wnt5a vasculogenic mimicry cancer stem cell epithelial-mesenchymal transition |
| title | Correlation Between Wnt5a Expression and Vasculogenic Mimicry in Prostate Cancer Tissues |
| title_full | Correlation Between Wnt5a Expression and Vasculogenic Mimicry in Prostate Cancer Tissues |
| title_fullStr | Correlation Between Wnt5a Expression and Vasculogenic Mimicry in Prostate Cancer Tissues |
| title_full_unstemmed | Correlation Between Wnt5a Expression and Vasculogenic Mimicry in Prostate Cancer Tissues |
| title_short | Correlation Between Wnt5a Expression and Vasculogenic Mimicry in Prostate Cancer Tissues |
| title_sort | correlation between wnt5a expression and vasculogenic mimicry in prostate cancer tissues |
| topic | prostate cancer wnt5a vasculogenic mimicry cancer stem cell epithelial-mesenchymal transition |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2024.23.0670 |
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