Comparison of 12-Week Additional Effect Features of Formoterol Co-Inhalation and Tulobuterol Patch on Budesonide Inhalation in Elderly Patients With Asthma
Background For asthma strategy, to avoid the aggravation of bronchial inflammation and contraction, the long acting beta agonist (LABA) addition on inhaled corticosteroids (ICS) has been recommended. Objectives To know whether there is any clinical difference between the additional efficacies of For...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-12-01
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| Series: | Allergy & Rhinology |
| Online Access: | https://doi.org/10.1177/2152656720980416 |
| _version_ | 1818664081909874688 |
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| author | Susumu Fukahori MD, PhD Tetsuya Kawano MD, PhD Yasushi Obase MD, PhD Jun Iriki MD Tomoko Tsuchida-Yabe MD, PhD Shinya Tomari MD, PhD Chizu Fukushima MD, PhD Hiroto Matsuse MD, PhD Hiroshi Mukae MD, PhD |
| author_facet | Susumu Fukahori MD, PhD Tetsuya Kawano MD, PhD Yasushi Obase MD, PhD Jun Iriki MD Tomoko Tsuchida-Yabe MD, PhD Shinya Tomari MD, PhD Chizu Fukushima MD, PhD Hiroto Matsuse MD, PhD Hiroshi Mukae MD, PhD |
| author_sort | Susumu Fukahori MD, PhD |
| collection | DOAJ |
| description | Background For asthma strategy, to avoid the aggravation of bronchial inflammation and contraction, the long acting beta agonist (LABA) addition on inhaled corticosteroids (ICS) has been recommended. Objectives To know whether there is any clinical difference between the additional efficacies of Formoterol (FOR) and Tulobuterol (TUL) onto Budesonide (BUD) may be useful for the elderly patients’ asthma treatment strategy. Methods Eighteen outpatients with mild to moderate bronchial asthma with FEV1.0% < 80% treated by intermediate ICS dosages visited Respiratory Division of Nagasaki University Hospital or Isahaya General Hospital, Japan Community Health care Organization were subjected, and were randomly assigned (9 cases per group) to either the FBC group (BUD/FOR 160/4.5 µg, 2 inhalations twice daily) or BUD + TUL group (BUD 200 mcg: 2 inhalations twice daily + TUL 2 mg daily) and were compared in parallel with 2 arms for 12 weeks prospectively. Peak expiratory flow, forced expiratory volume in 1 second, impulse oscillometry (IOS), fractional exhaled nitric oxide (FeNO), Asthma Control Questionnaire, mini-Asthma Quality of Life Questionnaire (mini-AQLQ), and occurrence of adverse reactions were compared. Results The “Fres” of IOS was improved in FBC group (p = 0.03). The “emotion” domain of mini-AQLQ was improved in BUD + TUL group (p = 0.03). Conclusion By changing the drug formulation, the patch was superior in terms of satisfaction, but it was thought that the inhaled combination was superior in improving the respiratory function itself. It is necessary to pay attention to the characteristics of the patient when selecting treatment. |
| first_indexed | 2024-12-17T05:27:05Z |
| format | Article |
| id | doaj.art-21f43a38a73b47e5878fd3adbae29dad |
| institution | Directory Open Access Journal |
| issn | 2152-6567 |
| language | English |
| last_indexed | 2024-12-17T05:27:05Z |
| publishDate | 2020-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Allergy & Rhinology |
| spelling | doaj.art-21f43a38a73b47e5878fd3adbae29dad2022-12-21T22:01:50ZengSAGE PublishingAllergy & Rhinology2152-65672020-12-011110.1177/2152656720980416Comparison of 12-Week Additional Effect Features of Formoterol Co-Inhalation and Tulobuterol Patch on Budesonide Inhalation in Elderly Patients With AsthmaSusumu Fukahori MD, PhDTetsuya Kawano MD, PhDYasushi Obase MD, PhDJun Iriki MDTomoko Tsuchida-Yabe MD, PhDShinya Tomari MD, PhDChizu Fukushima MD, PhDHiroto Matsuse MD, PhDHiroshi Mukae MD, PhDBackground For asthma strategy, to avoid the aggravation of bronchial inflammation and contraction, the long acting beta agonist (LABA) addition on inhaled corticosteroids (ICS) has been recommended. Objectives To know whether there is any clinical difference between the additional efficacies of Formoterol (FOR) and Tulobuterol (TUL) onto Budesonide (BUD) may be useful for the elderly patients’ asthma treatment strategy. Methods Eighteen outpatients with mild to moderate bronchial asthma with FEV1.0% < 80% treated by intermediate ICS dosages visited Respiratory Division of Nagasaki University Hospital or Isahaya General Hospital, Japan Community Health care Organization were subjected, and were randomly assigned (9 cases per group) to either the FBC group (BUD/FOR 160/4.5 µg, 2 inhalations twice daily) or BUD + TUL group (BUD 200 mcg: 2 inhalations twice daily + TUL 2 mg daily) and were compared in parallel with 2 arms for 12 weeks prospectively. Peak expiratory flow, forced expiratory volume in 1 second, impulse oscillometry (IOS), fractional exhaled nitric oxide (FeNO), Asthma Control Questionnaire, mini-Asthma Quality of Life Questionnaire (mini-AQLQ), and occurrence of adverse reactions were compared. Results The “Fres” of IOS was improved in FBC group (p = 0.03). The “emotion” domain of mini-AQLQ was improved in BUD + TUL group (p = 0.03). Conclusion By changing the drug formulation, the patch was superior in terms of satisfaction, but it was thought that the inhaled combination was superior in improving the respiratory function itself. It is necessary to pay attention to the characteristics of the patient when selecting treatment.https://doi.org/10.1177/2152656720980416 |
| spellingShingle | Susumu Fukahori MD, PhD Tetsuya Kawano MD, PhD Yasushi Obase MD, PhD Jun Iriki MD Tomoko Tsuchida-Yabe MD, PhD Shinya Tomari MD, PhD Chizu Fukushima MD, PhD Hiroto Matsuse MD, PhD Hiroshi Mukae MD, PhD Comparison of 12-Week Additional Effect Features of Formoterol Co-Inhalation and Tulobuterol Patch on Budesonide Inhalation in Elderly Patients With Asthma Allergy & Rhinology |
| title | Comparison of 12-Week Additional Effect Features of Formoterol Co-Inhalation and Tulobuterol Patch on Budesonide Inhalation in Elderly Patients With Asthma |
| title_full | Comparison of 12-Week Additional Effect Features of Formoterol Co-Inhalation and Tulobuterol Patch on Budesonide Inhalation in Elderly Patients With Asthma |
| title_fullStr | Comparison of 12-Week Additional Effect Features of Formoterol Co-Inhalation and Tulobuterol Patch on Budesonide Inhalation in Elderly Patients With Asthma |
| title_full_unstemmed | Comparison of 12-Week Additional Effect Features of Formoterol Co-Inhalation and Tulobuterol Patch on Budesonide Inhalation in Elderly Patients With Asthma |
| title_short | Comparison of 12-Week Additional Effect Features of Formoterol Co-Inhalation and Tulobuterol Patch on Budesonide Inhalation in Elderly Patients With Asthma |
| title_sort | comparison of 12 week additional effect features of formoterol co inhalation and tulobuterol patch on budesonide inhalation in elderly patients with asthma |
| url | https://doi.org/10.1177/2152656720980416 |
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