Role of Gut Microbiome in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects 8-13% of women at reproductive age worldwide. This disorder is usually associated with menstrual disorders, infertility, obesity, and insulin resistance. The underlying cause of this syndrome is unknown, however in recent...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2021-01-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-16072-en.html |
| _version_ | 1797958858542415872 |
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| author | Zekra Zaghi Seyed-Davar Siadat Hanieh-Sadat Ejtahed Nooshin Shirzad Shirin Hasani-Ranjbar Bagher Larijani |
| author_facet | Zekra Zaghi Seyed-Davar Siadat Hanieh-Sadat Ejtahed Nooshin Shirzad Shirin Hasani-Ranjbar Bagher Larijani |
| author_sort | Zekra Zaghi |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects 8-13% of women at reproductive age worldwide. This disorder is usually associated with menstrual disorders, infertility, obesity, and insulin resistance. The underlying cause of this syndrome is unknown, however in recent years, researchers have shown an association between intestinal microbiota alterations )dysbiosis( and many types of endocrine diseases. Therefore, this review article aimed to improve understanding about the role of intestinal microbiome in development and progression of polycystic ovary syndrome and the underlying mechanisms of this disease. Based on recent findings on the role of intestinal microbiota in the development of this disease, metabolic control may help to prevent that, however it is not yet conclusive. Exploring possible underlying mechanisms is of particular importance for providing new treatment approaches in women with polycystic ovary syndrome. Studies showed that modification of intestinal microbiome in women with PCOS using probiotics, prebiotics, synbiotics, and fecal microbiota transplantation could be effective in improving many of the symptoms of this syndrome and preventing further complications. Therefore, gut microbiota modification is recommended to be considered along with other common treatments. Of course, more research is needed in this field. |
| first_indexed | 2024-04-11T00:24:47Z |
| format | Article |
| id | doaj.art-21f4718cb4434f639ccbcc1fcb165cd8 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-11T00:24:47Z |
| publishDate | 2021-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-21f4718cb4434f639ccbcc1fcb165cd82023-01-08T08:42:38ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792021-01-0130193181199Role of Gut Microbiome in Polycystic Ovary SyndromeZekra Zaghi0Seyed-Davar Siadat1Hanieh-Sadat Ejtahed2Nooshin Shirzad3Shirin Hasani-Ranjbar4Bagher Larijani5 PhD Student in Microbiology, Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Professor, Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Assistant Professor, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Associate Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Professor, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects 8-13% of women at reproductive age worldwide. This disorder is usually associated with menstrual disorders, infertility, obesity, and insulin resistance. The underlying cause of this syndrome is unknown, however in recent years, researchers have shown an association between intestinal microbiota alterations )dysbiosis( and many types of endocrine diseases. Therefore, this review article aimed to improve understanding about the role of intestinal microbiome in development and progression of polycystic ovary syndrome and the underlying mechanisms of this disease. Based on recent findings on the role of intestinal microbiota in the development of this disease, metabolic control may help to prevent that, however it is not yet conclusive. Exploring possible underlying mechanisms is of particular importance for providing new treatment approaches in women with polycystic ovary syndrome. Studies showed that modification of intestinal microbiome in women with PCOS using probiotics, prebiotics, synbiotics, and fecal microbiota transplantation could be effective in improving many of the symptoms of this syndrome and preventing further complications. Therefore, gut microbiota modification is recommended to be considered along with other common treatments. Of course, more research is needed in this field.http://jmums.mazums.ac.ir/article-1-16072-en.htmlpolycystic ovary syndromegut microbiotamicrobiomedysbiosis |
| spellingShingle | Zekra Zaghi Seyed-Davar Siadat Hanieh-Sadat Ejtahed Nooshin Shirzad Shirin Hasani-Ranjbar Bagher Larijani Role of Gut Microbiome in Polycystic Ovary Syndrome Journal of Mazandaran University of Medical Sciences polycystic ovary syndrome gut microbiota microbiome dysbiosis |
| title | Role of Gut Microbiome in Polycystic Ovary Syndrome |
| title_full | Role of Gut Microbiome in Polycystic Ovary Syndrome |
| title_fullStr | Role of Gut Microbiome in Polycystic Ovary Syndrome |
| title_full_unstemmed | Role of Gut Microbiome in Polycystic Ovary Syndrome |
| title_short | Role of Gut Microbiome in Polycystic Ovary Syndrome |
| title_sort | role of gut microbiome in polycystic ovary syndrome |
| topic | polycystic ovary syndrome gut microbiota microbiome dysbiosis |
| url | http://jmums.mazums.ac.ir/article-1-16072-en.html |
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