Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat

Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat

<p>Abstract</p> <p>Background</p> <p>During HIV-1 infection, the Tat protein plays a key role by transactivating the transcription of the HIV-1 proviral DNA. In addition, Tat induces apoptosis of non-infected T lymphocytes, leading to a massive loss of immune competence...

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Bibliographic Details
Main Authors: Muller Sylviane, Chaloin Olivier, Allegro Diane, Piémont Etienne, Didier Pascal, Barbier Pascale, Egelé Caroline, Peyrot Vincent, Mély Yves
Format: Article
Language:English
Published: BMC 2008-07-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/5/1/62

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