Human protein interaction networks across tissues and diseases
Protein interaction networks are an important framework for studying protein function, cellular processes, and genotype-to-phenotype relationships. While our view of the human interactome is constantly expanding, less is known about networks that form in biologically important contexts such as withi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00257/full |
| _version_ | 1818199619123806208 |
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| author | Esti eYeger-Lotem Roded eSharan |
| author_facet | Esti eYeger-Lotem Roded eSharan |
| author_sort | Esti eYeger-Lotem |
| collection | DOAJ |
| description | Protein interaction networks are an important framework for studying protein function, cellular processes, and genotype-to-phenotype relationships. While our view of the human interactome is constantly expanding, less is known about networks that form in biologically important contexts such as within distinct tissues or in disease conditions. Here we review efforts to characterize these networks and to harness them to gain insights into the molecular mechanisms underlying human disease. |
| first_indexed | 2024-12-12T02:24:38Z |
| format | Article |
| id | doaj.art-21fde2024389418795ecdc629fd5627e |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-12T02:24:38Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-21fde2024389418795ecdc629fd5627e2022-12-22T00:41:35ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-08-01610.3389/fgene.2015.00257153767Human protein interaction networks across tissues and diseasesEsti eYeger-Lotem0Roded eSharan1Ben Gurion UniversityTel Aviv UniversityProtein interaction networks are an important framework for studying protein function, cellular processes, and genotype-to-phenotype relationships. While our view of the human interactome is constantly expanding, less is known about networks that form in biologically important contexts such as within distinct tissues or in disease conditions. Here we review efforts to characterize these networks and to harness them to gain insights into the molecular mechanisms underlying human disease.http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00257/fullGene ExpressionProtein Interaction Networknetwork perturbationtissue-specific networkdisease-specific network |
| spellingShingle | Esti eYeger-Lotem Roded eSharan Human protein interaction networks across tissues and diseases Frontiers in Genetics Gene Expression Protein Interaction Network network perturbation tissue-specific network disease-specific network |
| title | Human protein interaction networks across tissues and diseases |
| title_full | Human protein interaction networks across tissues and diseases |
| title_fullStr | Human protein interaction networks across tissues and diseases |
| title_full_unstemmed | Human protein interaction networks across tissues and diseases |
| title_short | Human protein interaction networks across tissues and diseases |
| title_sort | human protein interaction networks across tissues and diseases |
| topic | Gene Expression Protein Interaction Network network perturbation tissue-specific network disease-specific network |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00257/full |
| work_keys_str_mv | AT estieyegerlotem humanproteininteractionnetworksacrosstissuesanddiseases AT rodedesharan humanproteininteractionnetworksacrosstissuesanddiseases |