A GABAergic Dysfunction in the Olivary–Cerebellar–Brainstem Network May Cause Eye Oscillations and Body Tremor. II. Model Simulations of Saccadic Eye Oscillations
Eye and body oscillations are shared features of several neurological diseases, yet their pathophysiology remains unclear. Recently, we published a report on two tennis players with a novel presentation of eye and body oscillations following self-administration of performance-enhancing substances. O...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-08-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00372/full |
| _version_ | 1818199619378610176 |
|---|---|
| author | Lance M. Optican Elena Pretegiani |
| author_facet | Lance M. Optican Elena Pretegiani |
| author_sort | Lance M. Optican |
| collection | DOAJ |
| description | Eye and body oscillations are shared features of several neurological diseases, yet their pathophysiology remains unclear. Recently, we published a report on two tennis players with a novel presentation of eye and body oscillations following self-administration of performance-enhancing substances. Opsoclonus/flutter and limb tremor were diagnosed in both patients. Common causes of opsoclonus/flutter were excluded. High-resolution eye movement recordings from one patient showed novel spindle-shaped, asymmetric saccadic oscillations (at ~3.6 Hz) and ocular tremor (~40–60 Hz). Based on these findings, we proposed that the oscillations are the result of increased GABAA receptor sensitivity in a circuit involving the cerebellum (vermis and fastigial nuclei), the inferior olives, and the brainstem saccade premotor neurons (excitatory and inhibitory burst neurons, and omnipause neurons). We present a mathematical model of the saccadic system, showing that the proposed dysfunction in the network can reproduce the types of saccadic oscillations seen in these patients. |
| first_indexed | 2024-12-12T02:24:39Z |
| format | Article |
| id | doaj.art-21fe141057644532a8066ed331443c7a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T02:24:39Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-21fe141057644532a8066ed331443c7a2022-12-22T00:41:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-08-01810.3389/fneur.2017.00372274053A GABAergic Dysfunction in the Olivary–Cerebellar–Brainstem Network May Cause Eye Oscillations and Body Tremor. II. Model Simulations of Saccadic Eye OscillationsLance M. Optican0Elena Pretegiani1Laboratory of Sensorimotor Research, IRP, National Eye Institute, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Sensorimotor Research, IRP, National Eye Institute, National Institutes of Health, Bethesda, MD, United StatesEye and body oscillations are shared features of several neurological diseases, yet their pathophysiology remains unclear. Recently, we published a report on two tennis players with a novel presentation of eye and body oscillations following self-administration of performance-enhancing substances. Opsoclonus/flutter and limb tremor were diagnosed in both patients. Common causes of opsoclonus/flutter were excluded. High-resolution eye movement recordings from one patient showed novel spindle-shaped, asymmetric saccadic oscillations (at ~3.6 Hz) and ocular tremor (~40–60 Hz). Based on these findings, we proposed that the oscillations are the result of increased GABAA receptor sensitivity in a circuit involving the cerebellum (vermis and fastigial nuclei), the inferior olives, and the brainstem saccade premotor neurons (excitatory and inhibitory burst neurons, and omnipause neurons). We present a mathematical model of the saccadic system, showing that the proposed dysfunction in the network can reproduce the types of saccadic oscillations seen in these patients.http://journal.frontiersin.org/article/10.3389/fneur.2017.00372/fullsaccadevermisfastigial nucleiinferior oliveomnipause neuronseye movement |
| spellingShingle | Lance M. Optican Elena Pretegiani A GABAergic Dysfunction in the Olivary–Cerebellar–Brainstem Network May Cause Eye Oscillations and Body Tremor. II. Model Simulations of Saccadic Eye Oscillations Frontiers in Neurology saccade vermis fastigial nuclei inferior olive omnipause neurons eye movement |
| title | A GABAergic Dysfunction in the Olivary–Cerebellar–Brainstem Network May Cause Eye Oscillations and Body Tremor. II. Model Simulations of Saccadic Eye Oscillations |
| title_full | A GABAergic Dysfunction in the Olivary–Cerebellar–Brainstem Network May Cause Eye Oscillations and Body Tremor. II. Model Simulations of Saccadic Eye Oscillations |
| title_fullStr | A GABAergic Dysfunction in the Olivary–Cerebellar–Brainstem Network May Cause Eye Oscillations and Body Tremor. II. Model Simulations of Saccadic Eye Oscillations |
| title_full_unstemmed | A GABAergic Dysfunction in the Olivary–Cerebellar–Brainstem Network May Cause Eye Oscillations and Body Tremor. II. Model Simulations of Saccadic Eye Oscillations |
| title_short | A GABAergic Dysfunction in the Olivary–Cerebellar–Brainstem Network May Cause Eye Oscillations and Body Tremor. II. Model Simulations of Saccadic Eye Oscillations |
| title_sort | gabaergic dysfunction in the olivary cerebellar brainstem network may cause eye oscillations and body tremor ii model simulations of saccadic eye oscillations |
| topic | saccade vermis fastigial nuclei inferior olive omnipause neurons eye movement |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00372/full |
| work_keys_str_mv | AT lancemoptican agabaergicdysfunctionintheolivarycerebellarbrainstemnetworkmaycauseeyeoscillationsandbodytremoriimodelsimulationsofsaccadiceyeoscillations AT elenapretegiani agabaergicdysfunctionintheolivarycerebellarbrainstemnetworkmaycauseeyeoscillationsandbodytremoriimodelsimulationsofsaccadiceyeoscillations AT lancemoptican gabaergicdysfunctionintheolivarycerebellarbrainstemnetworkmaycauseeyeoscillationsandbodytremoriimodelsimulationsofsaccadiceyeoscillations AT elenapretegiani gabaergicdysfunctionintheolivarycerebellarbrainstemnetworkmaycauseeyeoscillationsandbodytremoriimodelsimulationsofsaccadiceyeoscillations |