Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder
Background: : Repetitive transcranial magnetic stimulation (rTMS) has attracted attention for treating treatment-resistant major depressive disorder (MDD) because of its effectiveness and low invasiveness. Recent neuroimaging studies suggest that the effects of rTMS in MDD may be based on improvemen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Journal of Affective Disorders Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915321001992 |
| _version_ | 1798016311818715136 |
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| author | Ryo Mitoma Shunsuke Tamura Hiroshi Tateishi Takako Mitsudo Ichiro Tanabe Akira Monji Yoji Hirano |
| author_facet | Ryo Mitoma Shunsuke Tamura Hiroshi Tateishi Takako Mitsudo Ichiro Tanabe Akira Monji Yoji Hirano |
| author_sort | Ryo Mitoma |
| collection | DOAJ |
| description | Background: : Repetitive transcranial magnetic stimulation (rTMS) has attracted attention for treating treatment-resistant major depressive disorder (MDD) because of its effectiveness and low invasiveness. Recent neuroimaging studies suggest that the effects of rTMS in MDD may be based on improvements in abnormal brain networks. However, oscillatory network changes after rTMS remain unclear. This study aimed to detect oscillatory electroencephalography (EEG) markers that reflect the therapeutic effects of rTMS. Methods: : We treated 15 treatment-resistant MDD patients with high-frequency (10 Hz) rTMS over the left prefrontal cortex for 6 weeks. The power spectral density at each electrode and the phase lag index between all electrode pairs were compared before and after rTMS using clinical EEG data. The relationships between EEG indices, depressive symptoms, and cognitive function were also examined. Results: : Depressive symptoms were significantly improved after rTMS. Additionally, functional connectivity between the left frontal–temporal and occipital regions in the theta band and gamma power in the anterior–central area were increased in both hemispheres after rTMS. Increased functional connectivity in the theta band was correlated with improved cognitive function, while increased gamma power was correlated with worsened depressive symptoms. Limitations: : The sample size was relatively small. Conclusion: : Our results demonstrated oscillatory changes in theta-band functional connectivity after rTMS in MDD patients. These findings, obtained using clinical EEG methods, provide evidence of the underlying neurophysiological effects of rTMS on MDD within the context of functional brain network changes, and may constitute a biomarker for evaluating MDD treatments. |
| first_indexed | 2024-04-11T15:48:52Z |
| format | Article |
| id | doaj.art-21fe7864099e4eecb064f3723c02d7f3 |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-04-11T15:48:52Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-21fe7864099e4eecb064f3723c02d7f32022-12-22T04:15:26ZengElsevierJournal of Affective Disorders Reports2666-91532022-01-017100277Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorderRyo Mitoma0Shunsuke Tamura1Hiroshi Tateishi2Takako Mitsudo3Ichiro Tanabe4Akira Monji5Yoji Hirano6Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Psychiatry, Saga University Hospital, Saga, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Psychiatry, Saga University Hospital, Saga, JapanDepartment of Psychiatry, Saga University Hospital, Saga, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Neural Dynamics Laboratory, Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Boston, USA; Corresponding author at: Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.Background: : Repetitive transcranial magnetic stimulation (rTMS) has attracted attention for treating treatment-resistant major depressive disorder (MDD) because of its effectiveness and low invasiveness. Recent neuroimaging studies suggest that the effects of rTMS in MDD may be based on improvements in abnormal brain networks. However, oscillatory network changes after rTMS remain unclear. This study aimed to detect oscillatory electroencephalography (EEG) markers that reflect the therapeutic effects of rTMS. Methods: : We treated 15 treatment-resistant MDD patients with high-frequency (10 Hz) rTMS over the left prefrontal cortex for 6 weeks. The power spectral density at each electrode and the phase lag index between all electrode pairs were compared before and after rTMS using clinical EEG data. The relationships between EEG indices, depressive symptoms, and cognitive function were also examined. Results: : Depressive symptoms were significantly improved after rTMS. Additionally, functional connectivity between the left frontal–temporal and occipital regions in the theta band and gamma power in the anterior–central area were increased in both hemispheres after rTMS. Increased functional connectivity in the theta band was correlated with improved cognitive function, while increased gamma power was correlated with worsened depressive symptoms. Limitations: : The sample size was relatively small. Conclusion: : Our results demonstrated oscillatory changes in theta-band functional connectivity after rTMS in MDD patients. These findings, obtained using clinical EEG methods, provide evidence of the underlying neurophysiological effects of rTMS on MDD within the context of functional brain network changes, and may constitute a biomarker for evaluating MDD treatments.http://www.sciencedirect.com/science/article/pii/S2666915321001992Repetitive transcranial magnetic stimulation (rTMS)Resting-state electroencephalogram (EEG)Gamma powerFunctional connectivityTreatment-resistant depression |
| spellingShingle | Ryo Mitoma Shunsuke Tamura Hiroshi Tateishi Takako Mitsudo Ichiro Tanabe Akira Monji Yoji Hirano Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder Journal of Affective Disorders Reports Repetitive transcranial magnetic stimulation (rTMS) Resting-state electroencephalogram (EEG) Gamma power Functional connectivity Treatment-resistant depression |
| title | Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder |
| title_full | Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder |
| title_fullStr | Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder |
| title_full_unstemmed | Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder |
| title_short | Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder |
| title_sort | oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder |
| topic | Repetitive transcranial magnetic stimulation (rTMS) Resting-state electroencephalogram (EEG) Gamma power Functional connectivity Treatment-resistant depression |
| url | http://www.sciencedirect.com/science/article/pii/S2666915321001992 |
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