No evidence of presence of parvovirus 4 in a Swedish cohort of severely immunocompromised children and adults.

The recently discovered human parvovirus 4 (PARV4) has been associated with seropositivity for human immunodeficiency virus, hepatitis B virus and hepatitis C virus. High prevalence is seen especially in intravenous drug users. The virus has been detected in blood products and persons who have been...

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Main Authors: Thomas Tolfvenstam, Oscar Norbeck, Lars Ohrmalm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458858?pdf=render
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author Thomas Tolfvenstam
Oscar Norbeck
Lars Ohrmalm
author_facet Thomas Tolfvenstam
Oscar Norbeck
Lars Ohrmalm
author_sort Thomas Tolfvenstam
collection DOAJ
description The recently discovered human parvovirus 4 (PARV4) has been associated with seropositivity for human immunodeficiency virus, hepatitis B virus and hepatitis C virus. High prevalence is seen especially in intravenous drug users. The virus has been detected in blood products and persons who have been repeatedly transfused have shown to be a risk-group. Furthermore, reports from different parts of the world suggesting a prevalence ranging from zero to one third of the healthy population and the virus is thought to cause a latent or persistent infection. We investigated the presence of PARV4 DNA and parvovirus B19 (B19) DNA in serum from 231 severely immunocompromised cancer patients that have been exposed for blood products. Compared to B19, which was found in 3.9% of the patients, we found no evidence of PARV4. Our results may indicate a very low prevalence of the virus in Sweden, and it would be useful to measure the real PARV4 exposure of the healthy population as well as individuals with known risk factors by serology.
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spelling doaj.art-21ff6834365947ed8f1a37d0a8d6d6322022-12-21T19:01:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4643010.1371/journal.pone.0046430No evidence of presence of parvovirus 4 in a Swedish cohort of severely immunocompromised children and adults.Thomas TolfvenstamOscar NorbeckLars OhrmalmThe recently discovered human parvovirus 4 (PARV4) has been associated with seropositivity for human immunodeficiency virus, hepatitis B virus and hepatitis C virus. High prevalence is seen especially in intravenous drug users. The virus has been detected in blood products and persons who have been repeatedly transfused have shown to be a risk-group. Furthermore, reports from different parts of the world suggesting a prevalence ranging from zero to one third of the healthy population and the virus is thought to cause a latent or persistent infection. We investigated the presence of PARV4 DNA and parvovirus B19 (B19) DNA in serum from 231 severely immunocompromised cancer patients that have been exposed for blood products. Compared to B19, which was found in 3.9% of the patients, we found no evidence of PARV4. Our results may indicate a very low prevalence of the virus in Sweden, and it would be useful to measure the real PARV4 exposure of the healthy population as well as individuals with known risk factors by serology.http://europepmc.org/articles/PMC3458858?pdf=render
spellingShingle Thomas Tolfvenstam
Oscar Norbeck
Lars Ohrmalm
No evidence of presence of parvovirus 4 in a Swedish cohort of severely immunocompromised children and adults.
PLoS ONE
title No evidence of presence of parvovirus 4 in a Swedish cohort of severely immunocompromised children and adults.
title_full No evidence of presence of parvovirus 4 in a Swedish cohort of severely immunocompromised children and adults.
title_fullStr No evidence of presence of parvovirus 4 in a Swedish cohort of severely immunocompromised children and adults.
title_full_unstemmed No evidence of presence of parvovirus 4 in a Swedish cohort of severely immunocompromised children and adults.
title_short No evidence of presence of parvovirus 4 in a Swedish cohort of severely immunocompromised children and adults.
title_sort no evidence of presence of parvovirus 4 in a swedish cohort of severely immunocompromised children and adults
url http://europepmc.org/articles/PMC3458858?pdf=render
work_keys_str_mv AT thomastolfvenstam noevidenceofpresenceofparvovirus4inaswedishcohortofseverelyimmunocompromisedchildrenandadults
AT oscarnorbeck noevidenceofpresenceofparvovirus4inaswedishcohortofseverelyimmunocompromisedchildrenandadults
AT larsohrmalm noevidenceofpresenceofparvovirus4inaswedishcohortofseverelyimmunocompromisedchildrenandadults