Phenomenology of COPD: interpreting phenotypes with the ECLIPSE study
The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational multicentre international study aimed at defining COPD phenotypes and identifying biomarkers and/or genetic parameters that help to predict disease progression. The stud...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-10-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/721 |
| _version_ | 1811285794183184384 |
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| author | Alberto Papi Maria Sandra Magnoni Carmelo Caio Muzzio Gianmarco Benso Andrea Rizzi |
| author_facet | Alberto Papi Maria Sandra Magnoni Carmelo Caio Muzzio Gianmarco Benso Andrea Rizzi |
| author_sort | Alberto Papi |
| collection | DOAJ |
| description | The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational multicentre international study aimed at defining COPD phenotypes and identifying biomarkers and/or genetic parameters that help to predict disease progression. The study has contributed to a better understanding of COPD heterogeneity, with the characterization of clinically important subtypes/phenotypes of patients, such as the frequent exacerbators or patient with persistent systemic inflammation, who may have different prognosis or treatment requirements. Because of the big amount of information that is starting to be produced from metabolomic, proteomic and genomic approaches, one of the biggest challenges is the integration of data in a biological prospective such as clinical prognosis and response to medicinal products. In this article we highlight some of the progress in phenotyping the heterogeneity of the disease that have been made thanks to the analyses of this longitudinal study. |
| first_indexed | 2024-04-13T02:49:16Z |
| format | Article |
| id | doaj.art-2201eb10547e4686a92d86e1025ca2f1 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-04-13T02:49:16Z |
| publishDate | 2016-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-2201eb10547e4686a92d86e1025ca2f12022-12-22T03:05:53ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642016-10-01831-210.4081/monaldi.2016.721Phenomenology of COPD: interpreting phenotypes with the ECLIPSE studyAlberto Papi0Maria Sandra Magnoni1Carmelo Caio Muzzio2Gianmarco Benso3Andrea Rizzi4University of FerraraGlaxoSmithKlineGlaxoSmithKlineGlaxoSmithKlineGlaxoSmithKlineThe Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational multicentre international study aimed at defining COPD phenotypes and identifying biomarkers and/or genetic parameters that help to predict disease progression. The study has contributed to a better understanding of COPD heterogeneity, with the characterization of clinically important subtypes/phenotypes of patients, such as the frequent exacerbators or patient with persistent systemic inflammation, who may have different prognosis or treatment requirements. Because of the big amount of information that is starting to be produced from metabolomic, proteomic and genomic approaches, one of the biggest challenges is the integration of data in a biological prospective such as clinical prognosis and response to medicinal products. In this article we highlight some of the progress in phenotyping the heterogeneity of the disease that have been made thanks to the analyses of this longitudinal study.https://www.monaldi-archives.org/index.php/macd/article/view/721COPDphenotypesexacerbationslung function. |
| spellingShingle | Alberto Papi Maria Sandra Magnoni Carmelo Caio Muzzio Gianmarco Benso Andrea Rizzi Phenomenology of COPD: interpreting phenotypes with the ECLIPSE study Monaldi Archives for Chest Disease COPD phenotypes exacerbations lung function. |
| title | Phenomenology of COPD: interpreting phenotypes with the ECLIPSE study |
| title_full | Phenomenology of COPD: interpreting phenotypes with the ECLIPSE study |
| title_fullStr | Phenomenology of COPD: interpreting phenotypes with the ECLIPSE study |
| title_full_unstemmed | Phenomenology of COPD: interpreting phenotypes with the ECLIPSE study |
| title_short | Phenomenology of COPD: interpreting phenotypes with the ECLIPSE study |
| title_sort | phenomenology of copd interpreting phenotypes with the eclipse study |
| topic | COPD phenotypes exacerbations lung function. |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/721 |
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