Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study
INTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and 2019 were retrospectively reviewed. The patie...
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| Format: | Article |
| Language: | English |
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Van Yuzuncu Yil University, School of Medicine
2021-01-01
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| Series: | Van Tıp Dergisi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-35336 |
| _version_ | 1827608436681998336 |
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| author | Özge Aşkın Ayşe Mine Gök Tuğba Kevser Uzunçakmak Zekayi Kutlubay |
| author_facet | Özge Aşkın Ayşe Mine Gök Tuğba Kevser Uzunçakmak Zekayi Kutlubay |
| author_sort | Özge Aşkın |
| collection | DOAJ |
| description | INTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and 2019 were retrospectively reviewed. The patients age, sex, diagnosis, presence of cutaneous/mucosal involvement before infusion, number of infusions, anti-desmoglein 1, anti-desmoglein 3 and indirect immunofluorescence data before and after treatment, treatment responses and side effects were recorded. RESULTS: In our study, we found a significant decrease in anti-desmoglein 1 and anti-desmoglein 3 levels and accumulations in indirect immunofluorescence after rituximab treatment. (P <0.001 for both) DISCUSSION AND CONCLUSION: The results from our study showed that rituximab is an effective agent that can be used with systemic steroid treatment. |
| first_indexed | 2024-03-09T07:13:02Z |
| format | Article |
| id | doaj.art-2202e044abd74b22bf4774dc754043e1 |
| institution | Directory Open Access Journal |
| issn | 2587-0351 |
| language | English |
| last_indexed | 2024-03-09T07:13:02Z |
| publishDate | 2021-01-01 |
| publisher | Van Yuzuncu Yil University, School of Medicine |
| record_format | Article |
| series | Van Tıp Dergisi |
| spelling | doaj.art-2202e044abd74b22bf4774dc754043e12023-12-03T08:55:10ZengVan Yuzuncu Yil University, School of MedicineVan Tıp Dergisi2587-03512021-01-0128113313610.5505/vtd.2021.35336VTD-35336Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort StudyÖzge Aşkın0Ayşe Mine Gök1Tuğba Kevser Uzunçakmak2Zekayi Kutlubay3Istanbul University, Cerrahpasa Medical Faculty, Department of Dermatology, IstanbulIstanbul University, Cerrahpasa Medical Faculty, Department of Dermatology, IstanbulIstanbul University, Cerrahpasa Medical Faculty, Department of Dermatology, IstanbulIstanbul University, Cerrahpasa Medical Faculty, Department of Dermatology, IstanbulINTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and 2019 were retrospectively reviewed. The patients age, sex, diagnosis, presence of cutaneous/mucosal involvement before infusion, number of infusions, anti-desmoglein 1, anti-desmoglein 3 and indirect immunofluorescence data before and after treatment, treatment responses and side effects were recorded. RESULTS: In our study, we found a significant decrease in anti-desmoglein 1 and anti-desmoglein 3 levels and accumulations in indirect immunofluorescence after rituximab treatment. (P <0.001 for both) DISCUSSION AND CONCLUSION: The results from our study showed that rituximab is an effective agent that can be used with systemic steroid treatment.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-35336anti-desmogleinbullous pemphigoidpemphigus vulgarisrituximab |
| spellingShingle | Özge Aşkın Ayşe Mine Gök Tuğba Kevser Uzunçakmak Zekayi Kutlubay Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study Van Tıp Dergisi anti-desmoglein bullous pemphigoid pemphigus vulgaris rituximab |
| title | Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study |
| title_full | Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study |
| title_fullStr | Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study |
| title_full_unstemmed | Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study |
| title_short | Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study |
| title_sort | efficacy of rituximab in patients with autoimmune bullous disease a retrospective cohort study |
| topic | anti-desmoglein bullous pemphigoid pemphigus vulgaris rituximab |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-35336 |
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