Neuronal Migration During Development of the Cerebellum
Neuronal migration is a fundamental process in central nervous system (CNS) development. The assembly of functioning neuronal circuits relies on neuronal migration occurring in the appropriate spatio-temporal pattern. A defect in the neuronal migration may result in a neurological disorder. The cere...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2018.00484/full |
| _version_ | 1818559984584097792 |
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| author | Maryam Rahimi-Balaei Maryam Rahimi-Balaei Hugo Bergen Jiming Kong Hassan Marzban Hassan Marzban |
| author_facet | Maryam Rahimi-Balaei Maryam Rahimi-Balaei Hugo Bergen Jiming Kong Hassan Marzban Hassan Marzban |
| author_sort | Maryam Rahimi-Balaei |
| collection | DOAJ |
| description | Neuronal migration is a fundamental process in central nervous system (CNS) development. The assembly of functioning neuronal circuits relies on neuronal migration occurring in the appropriate spatio-temporal pattern. A defect in the neuronal migration may result in a neurological disorder. The cerebellum, as a part of the CNS, plays a pivotal role in motor coordination and non-motor functions such as emotion, cognition and language. The excitatory and inhibitory neurons within the cerebellum originate from different distinct germinal zones and migrate through complex routes to assemble in a well-defined neuronal organization in the cerebellar cortex and nuclei. In this review article, the neuronal migration modes and pathways from germinal zones to the final position in the cerebellar cortex and nuclei will be described. The cellular and molecular mechanisms involved in cerebellar neuronal migration during development will also be reviewed. Finally, some diseases and animal models associated with defects in neuronal migration will be presented. |
| first_indexed | 2024-12-14T00:32:38Z |
| format | Article |
| id | doaj.art-220374a945074972a5fed0c707ca00dc |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-14T00:32:38Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-220374a945074972a5fed0c707ca00dc2022-12-21T23:24:46ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-12-011210.3389/fncel.2018.00484412612Neuronal Migration During Development of the CerebellumMaryam Rahimi-Balaei0Maryam Rahimi-Balaei1Hugo Bergen2Jiming Kong3Hassan Marzban4Hassan Marzban5Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaThe Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaThe Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaNeuronal migration is a fundamental process in central nervous system (CNS) development. The assembly of functioning neuronal circuits relies on neuronal migration occurring in the appropriate spatio-temporal pattern. A defect in the neuronal migration may result in a neurological disorder. The cerebellum, as a part of the CNS, plays a pivotal role in motor coordination and non-motor functions such as emotion, cognition and language. The excitatory and inhibitory neurons within the cerebellum originate from different distinct germinal zones and migrate through complex routes to assemble in a well-defined neuronal organization in the cerebellar cortex and nuclei. In this review article, the neuronal migration modes and pathways from germinal zones to the final position in the cerebellar cortex and nuclei will be described. The cellular and molecular mechanisms involved in cerebellar neuronal migration during development will also be reviewed. Finally, some diseases and animal models associated with defects in neuronal migration will be presented.https://www.frontiersin.org/article/10.3389/fncel.2018.00484/fullneuronmigrationcerebellumdevelopmentmechanism |
| spellingShingle | Maryam Rahimi-Balaei Maryam Rahimi-Balaei Hugo Bergen Jiming Kong Hassan Marzban Hassan Marzban Neuronal Migration During Development of the Cerebellum Frontiers in Cellular Neuroscience neuron migration cerebellum development mechanism |
| title | Neuronal Migration During Development of the Cerebellum |
| title_full | Neuronal Migration During Development of the Cerebellum |
| title_fullStr | Neuronal Migration During Development of the Cerebellum |
| title_full_unstemmed | Neuronal Migration During Development of the Cerebellum |
| title_short | Neuronal Migration During Development of the Cerebellum |
| title_sort | neuronal migration during development of the cerebellum |
| topic | neuron migration cerebellum development mechanism |
| url | https://www.frontiersin.org/article/10.3389/fncel.2018.00484/full |
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