Molecular Docking and Biophysical Studies for Antiproliferative Assessment of Synthetic Pyrazolo-Pyrimidinones Tethered with Hydrazide-Hydrazones

Molecular Docking and Biophysical Studies for Antiproliferative Assessment of Synthetic Pyrazolo-Pyrimidinones Tethered with Hydrazide-Hydrazones

Chemotherapy represents the most applied approach to cancer treatment. Owing to the frequent onset of chemoresistance and tumor relapses, there is an urgent need to discover novel and more effective anticancer drugs. In the search for therapeutic alternatives to treat the cancer disease, a series of...

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Bibliographic Details
Main Authors: Mabrouk Horchani, Gerardo Della Sala, Alessia Caso, Federica D’Aria, Germana Esposito, Ilaria Laurenzana, Concetta Giancola, Valeria Costantino, Hichem Ben Jannet, Anis Romdhane
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
pyrazolopyrimidinone
hydrazide-hydrazone
antitumor lead compound
cytotoxic activity
antiproliferative activity
molecular docking
Online Access:https://www.mdpi.com/1422-0067/22/5/2742

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