Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia
Ataxia telangiectasia (AT) is a rare autosomal recessive primary immunodeficiency disorder (PID) resulting from a mutation in the ATM gene, which is involved in DNA repair. We describe the case of a young girl with cutaneous granulomas that developed after childhood vaccinations. Immunohistochemist...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2024-04-01
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| Series: | Dermatology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/dr/article/view/9864 |
| _version_ | 1827287575699652608 |
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| author | Florine Le Lay Marianna Deparis Sylvie Fraitag Anne Dompmartin |
| author_facet | Florine Le Lay Marianna Deparis Sylvie Fraitag Anne Dompmartin |
| author_sort | Florine Le Lay |
| collection | DOAJ |
| description |
Ataxia telangiectasia (AT) is a rare autosomal recessive primary immunodeficiency disorder (PID) resulting from a mutation in the ATM gene, which is involved in DNA repair. We describe the case of a young girl with cutaneous granulomas that developed after childhood vaccinations. Immunohistochemistry revealed granulomas induced by the rubella virus vaccine. This finding raises the question of live rubella vaccine strains safety in immunocompromised children.
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| first_indexed | 2024-04-24T11:13:37Z |
| format | Article |
| id | doaj.art-2205aeb66a374376be5979a9d95f4482 |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-04-24T11:13:37Z |
| publishDate | 2024-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-2205aeb66a374376be5979a9d95f44822024-04-11T10:29:59ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062024-04-0110.4081/dr.2024.9864Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasiaFlorine Le Lay0Marianna Deparis1Sylvie Fraitag2Anne Dompmartin3Dermatology Department, Caen University Hospital, CaenPediatrics Department, Caen University Hospital, CaenPathology Department, Necker-Enfants Malades Hospital, ParisDermatology Department, Caen University Hospital, Caen Ataxia telangiectasia (AT) is a rare autosomal recessive primary immunodeficiency disorder (PID) resulting from a mutation in the ATM gene, which is involved in DNA repair. We describe the case of a young girl with cutaneous granulomas that developed after childhood vaccinations. Immunohistochemistry revealed granulomas induced by the rubella virus vaccine. This finding raises the question of live rubella vaccine strains safety in immunocompromised children. https://www.pagepress.org/journals/dr/article/view/9864Ataxia telangiectasiaimmunodeficiencyrubellagranulomavaccine |
| spellingShingle | Florine Le Lay Marianna Deparis Sylvie Fraitag Anne Dompmartin Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia Dermatology Reports Ataxia telangiectasia immunodeficiency rubella granuloma vaccine |
| title | Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia |
| title_full | Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia |
| title_fullStr | Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia |
| title_full_unstemmed | Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia |
| title_short | Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia |
| title_sort | rubella virus vaccine induced granulomas a case in children with ataxia telangiectasia |
| topic | Ataxia telangiectasia immunodeficiency rubella granuloma vaccine |
| url | https://www.pagepress.org/journals/dr/article/view/9864 |
| work_keys_str_mv | AT florinelelay rubellavirusvaccineinducedgranulomasacaseinchildrenwithataxiatelangiectasia AT mariannadeparis rubellavirusvaccineinducedgranulomasacaseinchildrenwithataxiatelangiectasia AT sylviefraitag rubellavirusvaccineinducedgranulomasacaseinchildrenwithataxiatelangiectasia AT annedompmartin rubellavirusvaccineinducedgranulomasacaseinchildrenwithataxiatelangiectasia |