Clinical Implications of Prominent Cortical Vessels on Susceptibility-Weighted Imaging in Acute Ischemic Stroke Patients Treated with Recanalization Therapy
Prominent cortical vessels on susceptibility-weighted imaging (PCV–SWI) correlate with poor leptomeningeal collaterals. However, little is known about PCV–SWI in recanalization therapy-treated patients with anterior circulation large vessel occlusions (LVO). We investigated PCV–SWI-based assessment...
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MDPI AG
2022-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/2/184 |
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| author | Misun Oh Minwoo Lee |
| author_facet | Misun Oh Minwoo Lee |
| author_sort | Misun Oh |
| collection | DOAJ |
| description | Prominent cortical vessels on susceptibility-weighted imaging (PCV–SWI) correlate with poor leptomeningeal collaterals. However, little is known about PCV–SWI in recanalization therapy-treated patients with anterior circulation large vessel occlusions (LVO). We investigated PCV–SWI-based assessment of leptomeningeal collaterals and outcome predictions in 100 such patients in an observational study. We assessed PCV–SWI using the Alberta Stroke Program Early CT Score and evaluated leptomeningeal collaterals on multiphase CT angiography (mCTA). Predictive abilities were analyzed using multivariable logistic regression and area of receiver operating curves (AUCs). The extent of PCV–SWI correlated with leptomeningeal collaterals on mCTA (Spearman test, <i>r</i> = 0.77; <i>p</i> < 0.001); their presence was associated with worse functional outcomes and a lower successful recanalization rate (adjusted odds ratios = 0.24 and 0.23, 95% CIs = 0.08–0.65 and 0.08–0.65, respectively). The presence of PCV–SWI predicted outcomes better than good collaterals on mCTA did (C-statistic = 0.84 vs. 0.80; 3-month modified Rankin Scale (mRS) 0–2 = 0.75 vs. 0.67 for successful recanalization). Comparison of AUCs showed that they had similar abilities for predicting outcomes (<i>p</i> = 0.68 for 3-month mRS 0–2; <i>p</i> = 0.23 for successful recanalization). These results suggest that PCV–SWI is a useful feature for assessing leptomeningeal collaterals in acute ischemic stroke patients with anterior circulation LVO and predicting outcomes after recanalization therapy. |
| first_indexed | 2024-03-09T22:27:42Z |
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| last_indexed | 2024-03-09T22:27:42Z |
| publishDate | 2022-01-01 |
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| spelling | doaj.art-2207fec2f367493982ed6fbd0c9691a32023-11-23T19:02:52ZengMDPI AGBrain Sciences2076-34252022-01-0112218410.3390/brainsci12020184Clinical Implications of Prominent Cortical Vessels on Susceptibility-Weighted Imaging in Acute Ischemic Stroke Patients Treated with Recanalization TherapyMisun Oh0Minwoo Lee1Department of Neurology, Hallym Neurological Institute, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, KoreaDepartment of Neurology, Hallym Neurological Institute, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, KoreaProminent cortical vessels on susceptibility-weighted imaging (PCV–SWI) correlate with poor leptomeningeal collaterals. However, little is known about PCV–SWI in recanalization therapy-treated patients with anterior circulation large vessel occlusions (LVO). We investigated PCV–SWI-based assessment of leptomeningeal collaterals and outcome predictions in 100 such patients in an observational study. We assessed PCV–SWI using the Alberta Stroke Program Early CT Score and evaluated leptomeningeal collaterals on multiphase CT angiography (mCTA). Predictive abilities were analyzed using multivariable logistic regression and area of receiver operating curves (AUCs). The extent of PCV–SWI correlated with leptomeningeal collaterals on mCTA (Spearman test, <i>r</i> = 0.77; <i>p</i> < 0.001); their presence was associated with worse functional outcomes and a lower successful recanalization rate (adjusted odds ratios = 0.24 and 0.23, 95% CIs = 0.08–0.65 and 0.08–0.65, respectively). The presence of PCV–SWI predicted outcomes better than good collaterals on mCTA did (C-statistic = 0.84 vs. 0.80; 3-month modified Rankin Scale (mRS) 0–2 = 0.75 vs. 0.67 for successful recanalization). Comparison of AUCs showed that they had similar abilities for predicting outcomes (<i>p</i> = 0.68 for 3-month mRS 0–2; <i>p</i> = 0.23 for successful recanalization). These results suggest that PCV–SWI is a useful feature for assessing leptomeningeal collaterals in acute ischemic stroke patients with anterior circulation LVO and predicting outcomes after recanalization therapy.https://www.mdpi.com/2076-3425/12/2/184prominent cortical vesselSWIleptomeningeal collateralsrecanalization therapyoutcomesstroke |
| spellingShingle | Misun Oh Minwoo Lee Clinical Implications of Prominent Cortical Vessels on Susceptibility-Weighted Imaging in Acute Ischemic Stroke Patients Treated with Recanalization Therapy Brain Sciences prominent cortical vessel SWI leptomeningeal collaterals recanalization therapy outcomes stroke |
| title | Clinical Implications of Prominent Cortical Vessels on Susceptibility-Weighted Imaging in Acute Ischemic Stroke Patients Treated with Recanalization Therapy |
| title_full | Clinical Implications of Prominent Cortical Vessels on Susceptibility-Weighted Imaging in Acute Ischemic Stroke Patients Treated with Recanalization Therapy |
| title_fullStr | Clinical Implications of Prominent Cortical Vessels on Susceptibility-Weighted Imaging in Acute Ischemic Stroke Patients Treated with Recanalization Therapy |
| title_full_unstemmed | Clinical Implications of Prominent Cortical Vessels on Susceptibility-Weighted Imaging in Acute Ischemic Stroke Patients Treated with Recanalization Therapy |
| title_short | Clinical Implications of Prominent Cortical Vessels on Susceptibility-Weighted Imaging in Acute Ischemic Stroke Patients Treated with Recanalization Therapy |
| title_sort | clinical implications of prominent cortical vessels on susceptibility weighted imaging in acute ischemic stroke patients treated with recanalization therapy |
| topic | prominent cortical vessel SWI leptomeningeal collaterals recanalization therapy outcomes stroke |
| url | https://www.mdpi.com/2076-3425/12/2/184 |
| work_keys_str_mv | AT misunoh clinicalimplicationsofprominentcorticalvesselsonsusceptibilityweightedimaginginacuteischemicstrokepatientstreatedwithrecanalizationtherapy AT minwoolee clinicalimplicationsofprominentcorticalvesselsonsusceptibilityweightedimaginginacuteischemicstrokepatientstreatedwithrecanalizationtherapy |