Failure of adaptive self-organized criticality during epileptic seizure attacks.
Critical dynamics are assumed to be an attractive mode for normal brain functioning as information processing and computational capabilities are found to be optimal in the critical state. Recent experimental observations of neuronal activity patterns following power-law distributions, a hallmark of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC3252275?pdf=render |
| _version_ | 1818296355953573888 |
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| author | Christian Meisel Alexander Storch Susanne Hallmeyer-Elgner Ed Bullmore Thilo Gross |
| author_facet | Christian Meisel Alexander Storch Susanne Hallmeyer-Elgner Ed Bullmore Thilo Gross |
| author_sort | Christian Meisel |
| collection | DOAJ |
| description | Critical dynamics are assumed to be an attractive mode for normal brain functioning as information processing and computational capabilities are found to be optimal in the critical state. Recent experimental observations of neuronal activity patterns following power-law distributions, a hallmark of systems at a critical state, have led to the hypothesis that human brain dynamics could be poised at a phase transition between ordered and disordered activity. A so far unresolved question concerns the medical significance of critical brain activity and how it relates to pathological conditions. Using data from invasive electroencephalogram recordings from humans we show that during epileptic seizure attacks neuronal activity patterns deviate from the normally observed power-law distribution characterizing critical dynamics. The comparison of these observations to results from a computational model exhibiting self-organized criticality (SOC) based on adaptive networks allows further insights into the underlying dynamics. Together these results suggest that brain dynamics deviates from criticality during seizures caused by the failure of adaptive SOC. |
| first_indexed | 2024-12-13T04:02:14Z |
| format | Article |
| id | doaj.art-2209517924244819810638046a9d65c5 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-13T04:02:14Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-2209517924244819810638046a9d65c52022-12-22T00:00:23ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582012-01-0181e100231210.1371/journal.pcbi.1002312Failure of adaptive self-organized criticality during epileptic seizure attacks.Christian MeiselAlexander StorchSusanne Hallmeyer-ElgnerEd BullmoreThilo GrossCritical dynamics are assumed to be an attractive mode for normal brain functioning as information processing and computational capabilities are found to be optimal in the critical state. Recent experimental observations of neuronal activity patterns following power-law distributions, a hallmark of systems at a critical state, have led to the hypothesis that human brain dynamics could be poised at a phase transition between ordered and disordered activity. A so far unresolved question concerns the medical significance of critical brain activity and how it relates to pathological conditions. Using data from invasive electroencephalogram recordings from humans we show that during epileptic seizure attacks neuronal activity patterns deviate from the normally observed power-law distribution characterizing critical dynamics. The comparison of these observations to results from a computational model exhibiting self-organized criticality (SOC) based on adaptive networks allows further insights into the underlying dynamics. Together these results suggest that brain dynamics deviates from criticality during seizures caused by the failure of adaptive SOC.http://europepmc.org/articles/PMC3252275?pdf=render |
| spellingShingle | Christian Meisel Alexander Storch Susanne Hallmeyer-Elgner Ed Bullmore Thilo Gross Failure of adaptive self-organized criticality during epileptic seizure attacks. PLoS Computational Biology |
| title | Failure of adaptive self-organized criticality during epileptic seizure attacks. |
| title_full | Failure of adaptive self-organized criticality during epileptic seizure attacks. |
| title_fullStr | Failure of adaptive self-organized criticality during epileptic seizure attacks. |
| title_full_unstemmed | Failure of adaptive self-organized criticality during epileptic seizure attacks. |
| title_short | Failure of adaptive self-organized criticality during epileptic seizure attacks. |
| title_sort | failure of adaptive self organized criticality during epileptic seizure attacks |
| url | http://europepmc.org/articles/PMC3252275?pdf=render |
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