Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort
Abstract To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthritis from A Coruña (PROCOAC). Demographic and clinic...
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55374-1 |
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| author | Maite Silva-Díaz Sonia Pértega-Díaz Vanesa Balboa-Barreiro Carlos M. Tilve-Álvarez Ana Raga-Sivira Ignacio Rego-Pérez Francisco J. Blanco Natividad Oreiro |
| author_facet | Maite Silva-Díaz Sonia Pértega-Díaz Vanesa Balboa-Barreiro Carlos M. Tilve-Álvarez Ana Raga-Sivira Ignacio Rego-Pérez Francisco J. Blanco Natividad Oreiro |
| author_sort | Maite Silva-Díaz |
| collection | DOAJ |
| description | Abstract To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthritis from A Coruña (PROCOAC). Demographic and clinical variables, obtained through questionnaires, clinical examinations, and patient analytics, were compared among individuals with hand OA, with and without EHOA. We performed appropriate univariate and multivariate stepwise regression analyses using SPSS v28. Among 1039 subjects diagnosed with hand OA, 303 exhibited EHOA. Multivariate logistic regression analysis revealed associations with inflamed joints, nodular hand OA, and total AUSCAN. Furthermore, the association with a lower prevalence of knee OA remained significant. The influence of metabolic syndrome (MetS) on EHOA patients was analyzed by including MetS as a covariate in the model. It was observed that MetS does not significantly impact the presence of EHOA, maintaining the effect size of other factors. In conclusion, in the PROCOAC cohort, EHOA is associated with nodular hand OA, inflammatory hand OA, and a higher total AUSCAN. However, EHOA is linked to a lower prevalence of knee OA. Importantly, in our cohort, no relationship was found between EHOA and MetS. |
| first_indexed | 2024-04-24T23:06:43Z |
| format | Article |
| id | doaj.art-220acdcf45f74a1d977a80ceccbac355 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T23:06:43Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-220acdcf45f74a1d977a80ceccbac3552024-03-17T12:25:27ZengNature PortfolioScientific Reports2045-23222024-03-011411910.1038/s41598-024-55374-1Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohortMaite Silva-Díaz0Sonia Pértega-Díaz1Vanesa Balboa-Barreiro2Carlos M. Tilve-Álvarez3Ana Raga-Sivira4Ignacio Rego-Pérez5Francisco J. Blanco6Natividad Oreiro7Grupo de Investigación Clinica en Reumatología (GIR), INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), SERGASGrupo de Investigación en Reumatología y Salud (GIR-S), Centro de Investigaciones Científicas Avanzadas (CICA), Universidade da CoruñaUnidad de Epidemiología Clínica y Bioestadística, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), SERGASAvances en Telemedicina e Informática Sanitaria (ATIS), INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), SERGASGrupo de Investigación Clinica en Reumatología (GIR), INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), SERGASGrupo de Investigación Clinica en Reumatología (GIR), INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), SERGASGrupo de Investigación Clinica en Reumatología (GIR), INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), SERGASGrupo de Investigación Clinica en Reumatología (GIR), INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), SERGASAbstract To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthritis from A Coruña (PROCOAC). Demographic and clinical variables, obtained through questionnaires, clinical examinations, and patient analytics, were compared among individuals with hand OA, with and without EHOA. We performed appropriate univariate and multivariate stepwise regression analyses using SPSS v28. Among 1039 subjects diagnosed with hand OA, 303 exhibited EHOA. Multivariate logistic regression analysis revealed associations with inflamed joints, nodular hand OA, and total AUSCAN. Furthermore, the association with a lower prevalence of knee OA remained significant. The influence of metabolic syndrome (MetS) on EHOA patients was analyzed by including MetS as a covariate in the model. It was observed that MetS does not significantly impact the presence of EHOA, maintaining the effect size of other factors. In conclusion, in the PROCOAC cohort, EHOA is associated with nodular hand OA, inflammatory hand OA, and a higher total AUSCAN. However, EHOA is linked to a lower prevalence of knee OA. Importantly, in our cohort, no relationship was found between EHOA and MetS.https://doi.org/10.1038/s41598-024-55374-1OsteoarthritisMetabolic syndromeRiskHand osteoarthritisKnee osteoarthritisChondrocytes |
| spellingShingle | Maite Silva-Díaz Sonia Pértega-Díaz Vanesa Balboa-Barreiro Carlos M. Tilve-Álvarez Ana Raga-Sivira Ignacio Rego-Pérez Francisco J. Blanco Natividad Oreiro Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort Scientific Reports Osteoarthritis Metabolic syndrome Risk Hand osteoarthritis Knee osteoarthritis Chondrocytes |
| title | Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort |
| title_full | Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort |
| title_fullStr | Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort |
| title_full_unstemmed | Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort |
| title_short | Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort |
| title_sort | metabolic syndrome is not associated with erosive hand osteoarthritis a cross sectional study using data from the procoac cohort |
| topic | Osteoarthritis Metabolic syndrome Risk Hand osteoarthritis Knee osteoarthritis Chondrocytes |
| url | https://doi.org/10.1038/s41598-024-55374-1 |
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