Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography Study
Previous studies have shown retinal vein occlusion (RVO) is associated with changes in vessel density visible on swept-source optical coherence tomography angiography (ss-OCTA). This study aimed to characterize retinal changes on ss-OCTA among RVO patients stratified by the need for continuous anti-...
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/10/2892 |
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| author | Brian T. Cheng Shubhendu Mishra John M. Bryan Saena A. Sadiq Nathan C. Sklar Emily G. Suen Taha O. Mohammed Rukhsana G. Mirza |
| author_facet | Brian T. Cheng Shubhendu Mishra John M. Bryan Saena A. Sadiq Nathan C. Sklar Emily G. Suen Taha O. Mohammed Rukhsana G. Mirza |
| author_sort | Brian T. Cheng |
| collection | DOAJ |
| description | Previous studies have shown retinal vein occlusion (RVO) is associated with changes in vessel density visible on swept-source optical coherence tomography angiography (ss-OCTA). This study aimed to characterize retinal changes on ss-OCTA among RVO patients stratified by the need for continuous anti-VEGF therapy. This cross-sectional study of 24 RVO patients ≥ 18 years were imaged with SS-OCT-A. Patients were categorized into continuous vs. limited therapy (≥1 vs. no injections in previous 12 months) based on recurrence of intraretinal fluid (IRF) on OCT. Images were analyzed using ImageJ. T-tests were used to compare vessel density of the macula and peripheral retina. Overall, RVO patients undergoing continuous therapy (<i>n</i> = 14) had higher diabetes prevalence, worse baseline visual acuity, and higher baseline macular thickness compared to the limited (<i>n</i> = 10) therapy group. Continuous therapy was associated with lower macular VD in the combined retina layer and the superficial capillary plexus (SCP), but not in the deep capillary plexus (DCP). Further, the continuous therapy group exhibited lower peripheral VD in the combined retina layer, and no difference in the SCP and DCP layers when analyzed separately. In conclusion, RVO patients requiring continuous anti-VEGF injections demonstrate reduced VD of the macula and in the periphery on SS-OCTA imaging. SS-OCTA may be valuable for monitoring and prognosticating treatment for RVO patients. |
| first_indexed | 2024-03-10T03:39:19Z |
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| id | doaj.art-220bb28592aa439dbdf507327a9fbf90 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:39:19Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-220bb28592aa439dbdf507327a9fbf902023-11-23T11:36:26ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011110289210.3390/jcm11102892Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography StudyBrian T. Cheng0Shubhendu Mishra1John M. Bryan2Saena A. Sadiq3Nathan C. Sklar4Emily G. Suen5Taha O. Mohammed6Rukhsana G. Mirza7Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USAPrevious studies have shown retinal vein occlusion (RVO) is associated with changes in vessel density visible on swept-source optical coherence tomography angiography (ss-OCTA). This study aimed to characterize retinal changes on ss-OCTA among RVO patients stratified by the need for continuous anti-VEGF therapy. This cross-sectional study of 24 RVO patients ≥ 18 years were imaged with SS-OCT-A. Patients were categorized into continuous vs. limited therapy (≥1 vs. no injections in previous 12 months) based on recurrence of intraretinal fluid (IRF) on OCT. Images were analyzed using ImageJ. T-tests were used to compare vessel density of the macula and peripheral retina. Overall, RVO patients undergoing continuous therapy (<i>n</i> = 14) had higher diabetes prevalence, worse baseline visual acuity, and higher baseline macular thickness compared to the limited (<i>n</i> = 10) therapy group. Continuous therapy was associated with lower macular VD in the combined retina layer and the superficial capillary plexus (SCP), but not in the deep capillary plexus (DCP). Further, the continuous therapy group exhibited lower peripheral VD in the combined retina layer, and no difference in the SCP and DCP layers when analyzed separately. In conclusion, RVO patients requiring continuous anti-VEGF injections demonstrate reduced VD of the macula and in the periphery on SS-OCTA imaging. SS-OCTA may be valuable for monitoring and prognosticating treatment for RVO patients.https://www.mdpi.com/2077-0383/11/10/2892retinal vein occlusionoptical coherence tomography angiographytreatment responseimaging |
| spellingShingle | Brian T. Cheng Shubhendu Mishra John M. Bryan Saena A. Sadiq Nathan C. Sklar Emily G. Suen Taha O. Mohammed Rukhsana G. Mirza Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography Study Journal of Clinical Medicine retinal vein occlusion optical coherence tomography angiography treatment response imaging |
| title | Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography Study |
| title_full | Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography Study |
| title_fullStr | Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography Study |
| title_full_unstemmed | Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography Study |
| title_short | Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography Study |
| title_sort | retinal vessel density and treatment intensity among adults with retinal vein occlusion a swept source optical coherence tomography angiography study |
| topic | retinal vein occlusion optical coherence tomography angiography treatment response imaging |
| url | https://www.mdpi.com/2077-0383/11/10/2892 |
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