Clinical and Radiological Parameters of HIV-Associated Pulmonary Tuberculosis in the Region with a High Prevalence of the Coinfection
The objective of the study: to compare clinical, social, and radiological parameters of respiratory tuberculosis in patients with different HIV statuses in the region with a high prevalence of the coinfection.Subjects and Methods. The retrospective study of medical files of 80 patients with pulmonar...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2021-09-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1569 |
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| author | Yu. V. Bazhenova E. Yu. Zorkaltseva S. N. Zhdanova O. A. Vorobieva N. Yu. Rozhkova |
| author_facet | Yu. V. Bazhenova E. Yu. Zorkaltseva S. N. Zhdanova O. A. Vorobieva N. Yu. Rozhkova |
| author_sort | Yu. V. Bazhenova |
| collection | DOAJ |
| description | The objective of the study: to compare clinical, social, and radiological parameters of respiratory tuberculosis in patients with different HIV statuses in the region with a high prevalence of the coinfection.Subjects and Methods. The retrospective study of medical files of 80 patients with pulmonary tuberculosis was conducted; patients were divided into 2 groups, 40 patients each: TB/HIV Group – patients with pulmonary tuberculosis and HIV infection, TB Group – patients with pulmonary tuberculosis and negative HIV status. The groups were comparable by gender and age. The groups were compared with each other by certain parameters.Results. Considering clinical signs, patients from TB/HIV Group suffered from more pronounced intoxication syndrome (χ2 = 10.476; p < 0.0012) and respiratory disorders such as severe shortness of breath with difficult inspiration (χ2 = 4.505; p < 0.03). Versus TB Group, patients in TB/HIV Group were more likely to have drug (χ2 = 10.7; p < 0.001) and alcohol addiction (χ2 = 4.21; p < 0.039), suffered from more disseminated disease (χ2 = 8.47 p < 0.003) with small proportion of pulmonary tissue destruction (χ2 = 5.8; p < 0.05), had pronounced intrathoracic lymphadenopathy (χ2 = 9.8; p = 0.0017) and pleural effusion (χ2 = 3.8; p < 0.05). Slower radiological improvement of tuberculous changes during treatment was detected in patients with TB/HIV co-infection versus HIV-negative patients (χ2 = 3.8; p < 0.05).Compared to CD4 lymphocytes > 200 cell/μl, when CD4 level ≤ 200 cell/μl, the frequency of radiological signs typical of tuberculosis such as alveolar infiltration, destruction of lung tissue decreased in chest CT, while the frequency of atypical manifestations (interstitial changes such as frosted glass) increased. |
| first_indexed | 2024-03-12T18:41:30Z |
| format | Article |
| id | doaj.art-220cc2da01d14292b113ccfe5e1e954d |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2025-03-14T09:56:31Z |
| publishDate | 2021-09-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-220cc2da01d14292b113ccfe5e1e954d2025-03-02T11:22:34ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062021-09-01999232910.21292/2075-1230-2021-99-9-23-291564Clinical and Radiological Parameters of HIV-Associated Pulmonary Tuberculosis in the Region with a High Prevalence of the CoinfectionYu. V. Bazhenova0E. Yu. Zorkaltseva1S. N. Zhdanova2O. A. Vorobieva3N. Yu. Rozhkova4Irkutsk State Medical Academy of Postgraduate Education – Branch of Russian Medical Academy of Continuing Professional EducationIrkutsk State Medical Academy of Postgraduate Education – Branch of Russian Medical Academy of Continuing Professional EducationResearch Center of Family Health and Reproduction ProblemsIrkutsk State Medical Academy of Postgraduate Education – Branch of Russian Medical Academy of Continuing Professional EducationIrkutsk State Medical Academy of Postgraduate Education – Branch of Russian Medical Academy of Continuing Professional EducationThe objective of the study: to compare clinical, social, and radiological parameters of respiratory tuberculosis in patients with different HIV statuses in the region with a high prevalence of the coinfection.Subjects and Methods. The retrospective study of medical files of 80 patients with pulmonary tuberculosis was conducted; patients were divided into 2 groups, 40 patients each: TB/HIV Group – patients with pulmonary tuberculosis and HIV infection, TB Group – patients with pulmonary tuberculosis and negative HIV status. The groups were comparable by gender and age. The groups were compared with each other by certain parameters.Results. Considering clinical signs, patients from TB/HIV Group suffered from more pronounced intoxication syndrome (χ2 = 10.476; p < 0.0012) and respiratory disorders such as severe shortness of breath with difficult inspiration (χ2 = 4.505; p < 0.03). Versus TB Group, patients in TB/HIV Group were more likely to have drug (χ2 = 10.7; p < 0.001) and alcohol addiction (χ2 = 4.21; p < 0.039), suffered from more disseminated disease (χ2 = 8.47 p < 0.003) with small proportion of pulmonary tissue destruction (χ2 = 5.8; p < 0.05), had pronounced intrathoracic lymphadenopathy (χ2 = 9.8; p = 0.0017) and pleural effusion (χ2 = 3.8; p < 0.05). Slower radiological improvement of tuberculous changes during treatment was detected in patients with TB/HIV co-infection versus HIV-negative patients (χ2 = 3.8; p < 0.05).Compared to CD4 lymphocytes > 200 cell/μl, when CD4 level ≤ 200 cell/μl, the frequency of radiological signs typical of tuberculosis such as alveolar infiltration, destruction of lung tissue decreased in chest CT, while the frequency of atypical manifestations (interstitial changes such as frosted glass) increased.https://www.tibl-journal.com/jour/article/view/1569respiratory tuberculosistuberculosis/hiv co-infectioncomputed tomography |
| spellingShingle | Yu. V. Bazhenova E. Yu. Zorkaltseva S. N. Zhdanova O. A. Vorobieva N. Yu. Rozhkova Clinical and Radiological Parameters of HIV-Associated Pulmonary Tuberculosis in the Region with a High Prevalence of the Coinfection Туберкулез и болезни лёгких respiratory tuberculosis tuberculosis/hiv co-infection computed tomography |
| title | Clinical and Radiological Parameters of HIV-Associated Pulmonary Tuberculosis in the Region with a High Prevalence of the Coinfection |
| title_full | Clinical and Radiological Parameters of HIV-Associated Pulmonary Tuberculosis in the Region with a High Prevalence of the Coinfection |
| title_fullStr | Clinical and Radiological Parameters of HIV-Associated Pulmonary Tuberculosis in the Region with a High Prevalence of the Coinfection |
| title_full_unstemmed | Clinical and Radiological Parameters of HIV-Associated Pulmonary Tuberculosis in the Region with a High Prevalence of the Coinfection |
| title_short | Clinical and Radiological Parameters of HIV-Associated Pulmonary Tuberculosis in the Region with a High Prevalence of the Coinfection |
| title_sort | clinical and radiological parameters of hiv associated pulmonary tuberculosis in the region with a high prevalence of the coinfection |
| topic | respiratory tuberculosis tuberculosis/hiv co-infection computed tomography |
| url | https://www.tibl-journal.com/jour/article/view/1569 |
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