Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA
We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child’s home just after his postmortem diagnosis...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2015-05-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/21/5/14-1992_article |
| _version_ | 1819059776896630784 |
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| author | Amy J. Lambert Rebecca Trout Fryxell Kimberly Freyman Armando Ulloa Jason O. Velez Dave Paulsen Robert Lanciotti Abelardo Moncayo |
| author_facet | Amy J. Lambert Rebecca Trout Fryxell Kimberly Freyman Armando Ulloa Jason O. Velez Dave Paulsen Robert Lanciotti Abelardo Moncayo |
| author_sort | Amy J. Lambert |
| collection | DOAJ |
| description | We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child’s home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes. |
| first_indexed | 2024-12-21T14:16:29Z |
| format | Article |
| id | doaj.art-220d6093a0a24f1cac3419d44574b701 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-21T14:16:29Z |
| publishDate | 2015-05-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-220d6093a0a24f1cac3419d44574b7012022-12-21T19:00:53ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-05-0121583383610.3201/eid2105.141992Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USAAmy J. LambertRebecca Trout FryxellKimberly FreymanArmando UlloaJason O. VelezDave PaulsenRobert LanciottiAbelardo MoncayoWe characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child’s home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes.https://wwwnc.cdc.gov/eid/article/21/5/14-1992_articleLa Crosse virusvirusessequenceTennesseechildrenvector-borne infections |
| spellingShingle | Amy J. Lambert Rebecca Trout Fryxell Kimberly Freyman Armando Ulloa Jason O. Velez Dave Paulsen Robert Lanciotti Abelardo Moncayo Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA Emerging Infectious Diseases La Crosse virus viruses sequence Tennessee children vector-borne infections |
| title | Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA |
| title_full | Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA |
| title_fullStr | Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA |
| title_full_unstemmed | Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA |
| title_short | Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA |
| title_sort | comparative sequence analyses of la crosse virus strain isolated from patient with fatal encephalitis tennessee usa |
| topic | La Crosse virus viruses sequence Tennessee children vector-borne infections |
| url | https://wwwnc.cdc.gov/eid/article/21/5/14-1992_article |
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