Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver Mitochondria
The search for new targets for the pathological action of ethanol remains an urgent task of biomedicine. Since degenerative changes in the liver are associated with the development of oxidative stress, antioxidants are promising agents for the treatment of alcohol-related diseases. In this work, we...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/10/2019 |
| _version_ | 1797475756293488640 |
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| author | Olga Krestinina Irina Odinokova Linda Sotnikova Roman Krestinin Alena Zvyagina Yulia Baburina |
| author_facet | Olga Krestinina Irina Odinokova Linda Sotnikova Roman Krestinin Alena Zvyagina Yulia Baburina |
| author_sort | Olga Krestinina |
| collection | DOAJ |
| description | The search for new targets for the pathological action of ethanol remains an urgent task of biomedicine. Since degenerative changes in the liver are associated with the development of oxidative stress, antioxidants are promising agents for the treatment of alcohol-related diseases. In this work, we studied the ability of the carotenoid antioxidant, astaxanthin (AX), to prevent ethanol-induced changes in the liver of rats. It was shown that AX is able to protect the structure of mitochondria from degenerative changes caused by ethanol to improve mitochondrial functions. AX positively influences the activity and expression of proteins of the mitochondrial respiratory chain complexes and ATPase. In addition, a protective effect of AX on the rate and activity of mitochondrial respiration was demonstrated in the work. Thus, studies have shown that AX is involved in protective mechanisms in response to ethanol-induced mitochondrial dysfunction. |
| first_indexed | 2024-03-09T20:48:19Z |
| format | Article |
| id | doaj.art-220f1f7eb1e74a5487c8ba7ffcbca2ab |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T20:48:19Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-220f1f7eb1e74a5487c8ba7ffcbca2ab2023-11-23T22:39:26ZengMDPI AGAntioxidants2076-39212022-10-011110201910.3390/antiox11102019Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver MitochondriaOlga Krestinina0Irina Odinokova1Linda Sotnikova2Roman Krestinin3Alena Zvyagina4Yulia Baburina5Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, RussiaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, RussiaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, RussiaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, RussiaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, RussiaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, RussiaThe search for new targets for the pathological action of ethanol remains an urgent task of biomedicine. Since degenerative changes in the liver are associated with the development of oxidative stress, antioxidants are promising agents for the treatment of alcohol-related diseases. In this work, we studied the ability of the carotenoid antioxidant, astaxanthin (AX), to prevent ethanol-induced changes in the liver of rats. It was shown that AX is able to protect the structure of mitochondria from degenerative changes caused by ethanol to improve mitochondrial functions. AX positively influences the activity and expression of proteins of the mitochondrial respiratory chain complexes and ATPase. In addition, a protective effect of AX on the rate and activity of mitochondrial respiration was demonstrated in the work. Thus, studies have shown that AX is involved in protective mechanisms in response to ethanol-induced mitochondrial dysfunction.https://www.mdpi.com/2076-3921/11/10/2019rat liver mitochondria (RLM)chronic ethanol intoxicationthe activity of respiratory chain complexesastaxanthin (AX) |
| spellingShingle | Olga Krestinina Irina Odinokova Linda Sotnikova Roman Krestinin Alena Zvyagina Yulia Baburina Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver Mitochondria Antioxidants rat liver mitochondria (RLM) chronic ethanol intoxication the activity of respiratory chain complexes astaxanthin (AX) |
| title | Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver Mitochondria |
| title_full | Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver Mitochondria |
| title_fullStr | Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver Mitochondria |
| title_full_unstemmed | Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver Mitochondria |
| title_short | Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver Mitochondria |
| title_sort | astaxanthin is able to prevent alcohol induced dysfunction of liver mitochondria |
| topic | rat liver mitochondria (RLM) chronic ethanol intoxication the activity of respiratory chain complexes astaxanthin (AX) |
| url | https://www.mdpi.com/2076-3921/11/10/2019 |
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