Isoforskolin modulates AQP4-SPP1-PIK3C3 related pathway for chronic obstructive pulmonary disease via cAMP signaling

Isoforskolin modulates AQP4-SPP1-PIK3C3 related pathway for chronic obstructive pulmonary disease via cAMP signaling

Abstract Background Cyclic adenosine monophosphate (cAMP) levels are directly activated by adenylate cyclase (AC) and play an anti-inflammatory role in chronic obstructive pulmonary disease (COPD). Previously, we have shown that isoforskolin (ISOF) can effectively activate AC1 and AC2 in vitro, impr...

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Bibliographic Details
Main Authors: Haochang Lin, Sha Cheng, Songye Yang, Qian Zhang, Lueli Wang, Jiangya Li, Xinyue Zhang, Liju Liang, Xiaoqian Zhou, Furong Yang, Jingfeng Song, Xue Cao, Weimin Yang, Zhiying Weng
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Chinese Medicine
Subjects:
ISOF
COPD
cAMP
Anti-inflammation
AQP4-SPP1-PIK3C3 signaling
Online Access:https://doi.org/10.1186/s13020-023-00778-w

Internet

https://doi.org/10.1186/s13020-023-00778-w

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