β-Elemene derivatives produced from SeO2-mediated oxidation reaction
Herein, we report the first access of β-elemene derivatives through the SeO2-mediated oxidation reaction. Several new compounds were isolated through such a one-step reaction, and their structures were elucidated using various 2D-NMR techniques. This method provides easy access to multiple oxidative...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2020-05-01
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| Series: | Royal Society Open Science |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200038 |
| _version_ | 1818340777725526016 |
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| author | Xingrui He Xiao-Tao Zhuo Yuan Gao Renren Bai Xiang-Yang Ye Tian Xie |
| author_facet | Xingrui He Xiao-Tao Zhuo Yuan Gao Renren Bai Xiang-Yang Ye Tian Xie |
| author_sort | Xingrui He |
| collection | DOAJ |
| description | Herein, we report the first access of β-elemene derivatives through the SeO2-mediated oxidation reaction. Several new compounds were isolated through such a one-step reaction, and their structures were elucidated using various 2D-NMR techniques. This method provides easy access to multiple oxidative β-elemene derivatives in one single step and represents the first modifications on cyclohexyl ring of β-elemene. It is expected to open up the opportunity for future derivatization on cyclohexyl ring of β-elemene. The new compounds obtained above showed better anti-proliferation activities than β-elemene itself on several cancer cell lines. Among them, compound 17 shows the best activity in antiproliferation assays of A549 and U-87MG cell lines. |
| first_indexed | 2024-12-13T15:48:18Z |
| format | Article |
| id | doaj.art-220fadb490834420bfcc3faa68170cd8 |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-13T15:48:18Z |
| publishDate | 2020-05-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-220fadb490834420bfcc3faa68170cd82022-12-21T23:39:37ZengThe Royal SocietyRoyal Society Open Science2054-57032020-05-017510.1098/rsos.200038200038β-Elemene derivatives produced from SeO2-mediated oxidation reactionXingrui HeXiao-Tao ZhuoYuan GaoRenren BaiXiang-Yang YeTian XieHerein, we report the first access of β-elemene derivatives through the SeO2-mediated oxidation reaction. Several new compounds were isolated through such a one-step reaction, and their structures were elucidated using various 2D-NMR techniques. This method provides easy access to multiple oxidative β-elemene derivatives in one single step and represents the first modifications on cyclohexyl ring of β-elemene. It is expected to open up the opportunity for future derivatization on cyclohexyl ring of β-elemene. The new compounds obtained above showed better anti-proliferation activities than β-elemene itself on several cancer cell lines. Among them, compound 17 shows the best activity in antiproliferation assays of A549 and U-87MG cell lines.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200038β-elemeneseo2cyclohexyl ring modificationsanti-proliferation |
| spellingShingle | Xingrui He Xiao-Tao Zhuo Yuan Gao Renren Bai Xiang-Yang Ye Tian Xie β-Elemene derivatives produced from SeO2-mediated oxidation reaction Royal Society Open Science β-elemene seo2 cyclohexyl ring modifications anti-proliferation |
| title | β-Elemene derivatives produced from SeO2-mediated oxidation reaction |
| title_full | β-Elemene derivatives produced from SeO2-mediated oxidation reaction |
| title_fullStr | β-Elemene derivatives produced from SeO2-mediated oxidation reaction |
| title_full_unstemmed | β-Elemene derivatives produced from SeO2-mediated oxidation reaction |
| title_short | β-Elemene derivatives produced from SeO2-mediated oxidation reaction |
| title_sort | β elemene derivatives produced from seo2 mediated oxidation reaction |
| topic | β-elemene seo2 cyclohexyl ring modifications anti-proliferation |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200038 |
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