Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia

Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia

SARS-CoV-2–induced excessive inflammation in brain leads to damage of blood–brain barrier, hypoxic-ischemic injury, and neuron degeneration. The production of inflammatory cytokines by brain microvascular endothelial cells and microglia is reported to be critically associated with the brain patholog...

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Bibliographic Details
Main Authors: Meng-Li Wu, Chengzuo Xie, Xin Li, Jing Sun, Jincun Zhao, Jian-Hua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
SARS-CoV-2
mast cell
neuroinflammation
tight junction protein
degranulation
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1358873/full

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