Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma
Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is an aggressive primary liver cancer with dismal outcome, high Ki-67 expression is associated with active progression and poor prognosis of iCCA, the application of MRE in the prediction of iCCA Ki-67 expression has not yet been investigate...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-11-01
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| Series: | Insights into Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13244-023-01559-7 |
| _version_ | 1797452385043349504 |
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| author | Shanshan Gao Wei Sun Yunfei Zhang Feihang Wang Kaipu Jin Xianling Qian Jing Han Xiaolin Wang Yongming Dai Ruofan Sheng Mengsu Zeng |
| author_facet | Shanshan Gao Wei Sun Yunfei Zhang Feihang Wang Kaipu Jin Xianling Qian Jing Han Xiaolin Wang Yongming Dai Ruofan Sheng Mengsu Zeng |
| author_sort | Shanshan Gao |
| collection | DOAJ |
| description | Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is an aggressive primary liver cancer with dismal outcome, high Ki-67 expression is associated with active progression and poor prognosis of iCCA, the application of MRE in the prediction of iCCA Ki-67 expression has not yet been investigated until now. We aimed to evaluate the value of magnetic resonance elastography (MRE) in assessing Ki-67 expression for iCCA. Results In the whole cohort, 97 patients (57 high Ki-67 and 40 low Ki-67; 58 males, 39 females; mean age, 58.89 years, ranges 36–70 years) were included. At the multivariate analysis, tumor stiffness (odds ratio (OR) = 1.669 [95% CI: 1.307–2.131], p < 0.001) and tumor apparent diffusion coefficient (ADC) (OR = 0.030 [95% CI: 0.002, 0.476], p = 0.013) were independent significant variables associated with Ki-67. Areas under the curve of tumor stiffness for the identification of high Ki-67 were 0.796 (95% CI 0.702, 0.871). Tumor stiffness was moderately correlated with Ki-67 level (r = 0.593, p < 0.001). When both predictive variables of tumor stiffness and ADC were integrated, the best performance was achieved with area under the curve values of 0.864 (95% CI 0.780–0.926). Conclusion MRE-based tumor stiffness correlated with Ki-67 in iCCA and could be investigated as a potential prognostic biomarker. The combined model incorporating both tumor stiffness and ADC increased the predictive performance. Critical relevance statement MRE-based tumor stiffness might be a surrogate imaging biomarker to predict Ki-67 expression in intrahepatic cholangiocarcinoma patients, reflecting tumor cellular proliferation. The combined model incorporating both tumor stiffness and apparent diffusion coefficient increased the predictive performance. Key points • MRE-based tumor stiffness shows a significant correlation with Ki-67. • The combined model incorporating tumor stiffness and apparent diffusion coefficient demonstrated an optimized predictive performance for Ki-67 expression. • MRE-based tumor stiffness could be investigated as a potential prognostic biomarker for intrahepatic cholangiocarcinoma. Graphical Abstract |
| first_indexed | 2024-03-09T15:07:36Z |
| format | Article |
| id | doaj.art-221408c502a24b35814eae8ccf51d36d |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-03-09T15:07:36Z |
| publishDate | 2023-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-221408c502a24b35814eae8ccf51d36d2023-11-26T13:32:58ZengSpringerOpenInsights into Imaging1869-41012023-11-0114111110.1186/s13244-023-01559-7Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinomaShanshan Gao0Wei Sun1Yunfei Zhang2Feihang Wang3Kaipu Jin4Xianling Qian5Jing Han6Xiaolin Wang7Yongming Dai8Ruofan Sheng9Mengsu Zeng10Department of Radiology, Zhongshan Hospital, Fudan UniversityDepartment of Radiology, Zhongshan Hospital, Fudan UniversityShanghai Institute of Medical ImagingShanghai Institute of Medical ImagingDepartment of Radiology, Zhongshan Hospital, Fudan UniversityDepartment of Radiology, Zhongshan Hospital, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, Fudan UniversityShanghai Institute of Medical ImagingCentral Research Institute, United Imaging HealthcareDepartment of Radiology, Zhongshan Hospital, Fudan UniversityDepartment of Radiology, Zhongshan Hospital, Fudan UniversityAbstract Background Intrahepatic cholangiocarcinoma (iCCA) is an aggressive primary liver cancer with dismal outcome, high Ki-67 expression is associated with active progression and poor prognosis of iCCA, the application of MRE in the prediction of iCCA Ki-67 expression has not yet been investigated until now. We aimed to evaluate the value of magnetic resonance elastography (MRE) in assessing Ki-67 expression for iCCA. Results In the whole cohort, 97 patients (57 high Ki-67 and 40 low Ki-67; 58 males, 39 females; mean age, 58.89 years, ranges 36–70 years) were included. At the multivariate analysis, tumor stiffness (odds ratio (OR) = 1.669 [95% CI: 1.307–2.131], p < 0.001) and tumor apparent diffusion coefficient (ADC) (OR = 0.030 [95% CI: 0.002, 0.476], p = 0.013) were independent significant variables associated with Ki-67. Areas under the curve of tumor stiffness for the identification of high Ki-67 were 0.796 (95% CI 0.702, 0.871). Tumor stiffness was moderately correlated with Ki-67 level (r = 0.593, p < 0.001). When both predictive variables of tumor stiffness and ADC were integrated, the best performance was achieved with area under the curve values of 0.864 (95% CI 0.780–0.926). Conclusion MRE-based tumor stiffness correlated with Ki-67 in iCCA and could be investigated as a potential prognostic biomarker. The combined model incorporating both tumor stiffness and ADC increased the predictive performance. Critical relevance statement MRE-based tumor stiffness might be a surrogate imaging biomarker to predict Ki-67 expression in intrahepatic cholangiocarcinoma patients, reflecting tumor cellular proliferation. The combined model incorporating both tumor stiffness and apparent diffusion coefficient increased the predictive performance. Key points • MRE-based tumor stiffness shows a significant correlation with Ki-67. • The combined model incorporating tumor stiffness and apparent diffusion coefficient demonstrated an optimized predictive performance for Ki-67 expression. • MRE-based tumor stiffness could be investigated as a potential prognostic biomarker for intrahepatic cholangiocarcinoma. Graphical Abstracthttps://doi.org/10.1186/s13244-023-01559-7Intrahepatic cholangiocarcinomaMagnetic resonance elastographyKi-67 |
| spellingShingle | Shanshan Gao Wei Sun Yunfei Zhang Feihang Wang Kaipu Jin Xianling Qian Jing Han Xiaolin Wang Yongming Dai Ruofan Sheng Mengsu Zeng Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma Insights into Imaging Intrahepatic cholangiocarcinoma Magnetic resonance elastography Ki-67 |
| title | Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma |
| title_full | Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma |
| title_fullStr | Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma |
| title_full_unstemmed | Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma |
| title_short | Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma |
| title_sort | correlation analysis of mr elastography and ki 67 expression in intrahepatic cholangiocarcinoma |
| topic | Intrahepatic cholangiocarcinoma Magnetic resonance elastography Ki-67 |
| url | https://doi.org/10.1186/s13244-023-01559-7 |
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