Three cardinal numbers to safeguard bees against pesticide exposure: LD₅₀ , NOEC (revised) and the Haber exponent
Regulators often employ cardinal indicators to justify measures to protect the health of farmland bees from pesticides used in crop protection. Previously, in evaluating the likely hazard of a compound, they have made extensive use of its LD 50 (‘lethal dose to 50% of exposed subjects’), and NOEC (‘...
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| Format: | Article |
| Language: | deu |
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Julius Kühn-Institut
2018-07-01
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| Series: | Julius-Kühn-Archiv |
| Online Access: | https://www.openagrar.de/receive/openagrar_mods_00040856 |
| _version_ | 1797467631521890304 |
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| author | Cresswell, James E. |
| author_facet | Cresswell, James E. |
| author_sort | Cresswell, James E. |
| collection | DOAJ |
| description | Regulators often employ cardinal indicators to justify measures to protect the health of farmland bees from pesticides used in crop protection. Previously, in evaluating the likely hazard of a compound, they have made extensive use of its LD 50 (‘lethal dose to 50% of exposed subjects’), and NOEC (‘no observable effect concentration’). Here, I argue that regulators should also use a third indicator, namely the Haber exponent. The Haber exponent qualifies the meaning of the LD 50 by revealing the relative hazard of environmentally relevant exposures longer than that used to determine the LD 50 originally. Additionally, I show how the experimental protocol used to determine the Haber exponent will also produce a well-founded, parametric value of the NOEC. Taken together, these three numbers establish a strong foundation on which to evaluate the potential impact of an agrochemical on bees. |
| first_indexed | 2024-03-09T18:56:26Z |
| format | Article |
| id | doaj.art-2214d055a15a438cbf6313ba440db4dc |
| institution | Directory Open Access Journal |
| issn | 1868-9892 2199-921X |
| language | deu |
| last_indexed | 2024-03-09T18:56:26Z |
| publishDate | 2018-07-01 |
| publisher | Julius Kühn-Institut |
| record_format | Article |
| series | Julius-Kühn-Archiv |
| spelling | doaj.art-2214d055a15a438cbf6313ba440db4dc2023-11-24T05:25:28ZdeuJulius Kühn-InstitutJulius-Kühn-Archiv1868-98922199-921X2018-07-01462182410.5073/jka.2018.462.003Three cardinal numbers to safeguard bees against pesticide exposure: LD₅₀ , NOEC (revised) and the Haber exponent Cresswell, James E. 0Biosciences, University of Exeter, Exeter, UKRegulators often employ cardinal indicators to justify measures to protect the health of farmland bees from pesticides used in crop protection. Previously, in evaluating the likely hazard of a compound, they have made extensive use of its LD 50 (‘lethal dose to 50% of exposed subjects’), and NOEC (‘no observable effect concentration’). Here, I argue that regulators should also use a third indicator, namely the Haber exponent. The Haber exponent qualifies the meaning of the LD 50 by revealing the relative hazard of environmentally relevant exposures longer than that used to determine the LD 50 originally. Additionally, I show how the experimental protocol used to determine the Haber exponent will also produce a well-founded, parametric value of the NOEC. Taken together, these three numbers establish a strong foundation on which to evaluate the potential impact of an agrochemical on bees.https://www.openagrar.de/receive/openagrar_mods_00040856 |
| spellingShingle | Cresswell, James E. Three cardinal numbers to safeguard bees against pesticide exposure: LD₅₀ , NOEC (revised) and the Haber exponent Julius-Kühn-Archiv |
| title | Three cardinal numbers to safeguard bees against pesticide exposure: LD₅₀ , NOEC (revised) and the Haber exponent |
| title_full | Three cardinal numbers to safeguard bees against pesticide exposure: LD₅₀ , NOEC (revised) and the Haber exponent |
| title_fullStr | Three cardinal numbers to safeguard bees against pesticide exposure: LD₅₀ , NOEC (revised) and the Haber exponent |
| title_full_unstemmed | Three cardinal numbers to safeguard bees against pesticide exposure: LD₅₀ , NOEC (revised) and the Haber exponent |
| title_short | Three cardinal numbers to safeguard bees against pesticide exposure: LD₅₀ , NOEC (revised) and the Haber exponent |
| title_sort | three cardinal numbers to safeguard bees against pesticide exposure ld₅₀ noec revised and the haber exponent |
| url | https://www.openagrar.de/receive/openagrar_mods_00040856 |
| work_keys_str_mv | AT cresswelljamese threecardinalnumberstosafeguardbeesagainstpesticideexposureld50noecrevisedandthehaberexponent |