An SEIR model of influenza A virus infection and reinfection within a farrow-to-finish swine farm.
Influenza A virus (IAV) in swine is a pathogen that causes a threat to the health as well as to the production of swine. Moreover, swine can spread this virus to other species including humans. The virus persists in different types of swine farms as evident in a number of studies. The core objective...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0202493 |
| _version_ | 1819147187027705856 |
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| author | Fatima Etbaigha Allan R Willms Zvonimir Poljak |
| author_facet | Fatima Etbaigha Allan R Willms Zvonimir Poljak |
| author_sort | Fatima Etbaigha |
| collection | DOAJ |
| description | Influenza A virus (IAV) in swine is a pathogen that causes a threat to the health as well as to the production of swine. Moreover, swine can spread this virus to other species including humans. The virus persists in different types of swine farms as evident in a number of studies. The core objectives of this study are (i) to analyze the dynamics of influenza infection of a farrow-to-finish swine farm, (ii) to explore the reinfection at the farm level, and finally (iii) to examine the effectiveness of two control strategies: vaccination and reduction of indirect contact. The analyses are conducted using a deterministic Susceptible-Exposed-Infectious-Recovered (SEIR) model. Simulation results show that the disease is maintained in gilts and piglets because of new susceptible pigs entering the population on a weekly basis. A sensitivity analysis shows that the results are not sensitive to variation in the parameters. The results of the reinfection simulation indicate that the virus persists in the entire farm. The control strategies studied in this work are not successful in eliminating the virus within the farm. |
| first_indexed | 2024-12-22T13:25:50Z |
| format | Article |
| id | doaj.art-221a31d2f0db4785b7c46d43565559d9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T13:25:50Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-221a31d2f0db4785b7c46d43565559d92022-12-21T18:24:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01139e020249310.1371/journal.pone.0202493An SEIR model of influenza A virus infection and reinfection within a farrow-to-finish swine farm.Fatima EtbaighaAllan R WillmsZvonimir PoljakInfluenza A virus (IAV) in swine is a pathogen that causes a threat to the health as well as to the production of swine. Moreover, swine can spread this virus to other species including humans. The virus persists in different types of swine farms as evident in a number of studies. The core objectives of this study are (i) to analyze the dynamics of influenza infection of a farrow-to-finish swine farm, (ii) to explore the reinfection at the farm level, and finally (iii) to examine the effectiveness of two control strategies: vaccination and reduction of indirect contact. The analyses are conducted using a deterministic Susceptible-Exposed-Infectious-Recovered (SEIR) model. Simulation results show that the disease is maintained in gilts and piglets because of new susceptible pigs entering the population on a weekly basis. A sensitivity analysis shows that the results are not sensitive to variation in the parameters. The results of the reinfection simulation indicate that the virus persists in the entire farm. The control strategies studied in this work are not successful in eliminating the virus within the farm.https://doi.org/10.1371/journal.pone.0202493 |
| spellingShingle | Fatima Etbaigha Allan R Willms Zvonimir Poljak An SEIR model of influenza A virus infection and reinfection within a farrow-to-finish swine farm. PLoS ONE |
| title | An SEIR model of influenza A virus infection and reinfection within a farrow-to-finish swine farm. |
| title_full | An SEIR model of influenza A virus infection and reinfection within a farrow-to-finish swine farm. |
| title_fullStr | An SEIR model of influenza A virus infection and reinfection within a farrow-to-finish swine farm. |
| title_full_unstemmed | An SEIR model of influenza A virus infection and reinfection within a farrow-to-finish swine farm. |
| title_short | An SEIR model of influenza A virus infection and reinfection within a farrow-to-finish swine farm. |
| title_sort | seir model of influenza a virus infection and reinfection within a farrow to finish swine farm |
| url | https://doi.org/10.1371/journal.pone.0202493 |
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