Pharmaco-Optogenetic Targeting of TRPC Activity Allows for Precise Control Over Mast Cell NFAT Signaling

Pharmaco-Optogenetic Targeting of TRPC Activity Allows for Precise Control Over Mast Cell NFAT Signaling

Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca2+ handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses. Utilizing a recently established TRPC3/6/7 selective, photo...

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Bibliographic Details
Main Authors: Bernadett Bacsa, Annarita Graziani, Denis Krivic, Patrick Wiedner, Roland Malli, Thomas Rauter, Oleksandra Tiapko, Klaus Groschner
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
canonical transient receptor potential channels
mast cells
opto-chemical immunomodulation
NFAT nuclear translocation
photopharmacology
OptoBI-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.613194/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.613194/full

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