Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors.

Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors.

Several novel bisbenzylisoquinoline alkaloids (BBIQAs) have recently been isolated from a Matis tribe arrow poison and shown by two-electrode voltage-clamp to inhibit mouse muscle nicotinic acetylcholine receptors (nAChR). Here, using radioligand assay with Aplysia californica AChBP and radioiodinat...

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Main Authors: Ekaterina N Spirova, Igor A Ivanov, Igor E Kasheverov, Denis S Kudryavtsev, Irina V Shelukhina, Alexandra I Garifulina, Lina V Son, Sarah C R Lummis, Gonzalo R Malca-Garcia, Rainer W Bussmann, Lothar Hennig, Athanassios Giannis, Victor I Tsetlin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210182

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