Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease

Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease

<p>Abstract</p> <p>Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein expression in AD is still elusive. Activated glia...

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Bibliographic Details
Main Authors: Arendt Thomas, Veerhuis Robert, van Haastert Elise S, Hoozemans Jeroen JM, Scheper Wiep, Eikelenboom Piet, Rozemuller Annemieke JM
Format: Article
Language:English
Published: BMC 2005-11-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer's disease
astrocytes
cell cycle
cyclooxygenase-2
microglia
retinoblastoma protein
Online Access:http://www.jneuroinflammation.com/content/2/1/27

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