Causal association between sleep traits and the risk of coronary artery disease in patients with diabetes
Background and aimsThe association between sleep traits and coronary artery disease (CAD) in patients with diabetes has been reported in previous observational studies. However, whether these potential relationships are causal remains unclear. We aim to assess the causal relationship between sleep t...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1132281/full |
| _version_ | 1811160732704702464 |
|---|---|
| author | Mengyun Tian Hongchuang Ma Hongchuang Ma Hongchuang Ma Jiaxi Shen Jiaxi Shen Teng Hu Hanbin Cui Hanbin Cui Hanbin Cui Ning Huangfu Ning Huangfu Ning Huangfu |
| author_facet | Mengyun Tian Hongchuang Ma Hongchuang Ma Hongchuang Ma Jiaxi Shen Jiaxi Shen Teng Hu Hanbin Cui Hanbin Cui Hanbin Cui Ning Huangfu Ning Huangfu Ning Huangfu |
| author_sort | Mengyun Tian |
| collection | DOAJ |
| description | Background and aimsThe association between sleep traits and coronary artery disease (CAD) in patients with diabetes has been reported in previous observational studies. However, whether these potential relationships are causal remains unclear. We aim to assess the causal relationship between sleep traits and CAD in diabetic.MethodsGenetic instrumental variables associated with five sleep-related traits (insomnia, sleep duration, ease of getting up, morningness and snoring) were extracted from corresponding genome-wide association studies (GWAS). The associations of genetic variants with CAD were based on 15,666 individuals with diabetes (3,968 CAD cases and 11,696 controls). The primary analysis was derived using the inverse variance weighting method. Further sensitivity analysis was conducted to confirm the robustness and consistency of the main results.ResultsGenetic liability to insomnia was significantly related to the increased risk of CAD in individuals with diabetes [odds ratio (OR): 1.163; 95% CI: 1.072–1.254; p = 0.001]. Suggestive evidence was found for the borderline associations between both sleep duration (OR: 0.629; 95% CI: 0.380–1.042, p = 0.072) and snoring (OR: 1.010, 95% CI: 1.000–1.020, p = 0.050) with CAD risk. However, no consistent evidence was found for the association between ease of getting up and morningness with the risk of CAD in diabetic. Similar results can be verified in most sensitivity analyses.ConclusionsWe provide consistent evidence for the causal effect of insomnia on the increased risk of CAD in individuals with diabetes. The management of sleep health should be emphasized to prevent CAD in diabetic patients. |
| first_indexed | 2024-04-10T06:02:25Z |
| format | Article |
| id | doaj.art-22202789101d49f985e4ca3e93265360 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T06:02:25Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-22202789101d49f985e4ca3e932653602023-03-03T06:18:25ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.11322811132281Causal association between sleep traits and the risk of coronary artery disease in patients with diabetesMengyun Tian0Hongchuang Ma1Hongchuang Ma2Hongchuang Ma3Jiaxi Shen4Jiaxi Shen5Teng Hu6Hanbin Cui7Hanbin Cui8Hanbin Cui9Ning Huangfu10Ning Huangfu11Ning Huangfu12School of Medicine, Ningbo University, Ningbo, ChinaDepartment of Cardiology, Ningbo First Hospital, Ningbo, ChinaDepartment of Cardiology, Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, ChinaClinical Medicine Research Centre for Cardiovascular Disease of Ningbo, Ningbo, ChinaDepartment of Cardiology, Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, ChinaClinical Medicine Research Centre for Cardiovascular Disease of Ningbo, Ningbo, ChinaSchool of Medicine, Ningbo University, Ningbo, ChinaDepartment of Cardiology, Ningbo First Hospital, Ningbo, ChinaDepartment of Cardiology, Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, ChinaClinical Medicine Research Centre for Cardiovascular Disease of Ningbo, Ningbo, ChinaDepartment of Cardiology, Ningbo First Hospital, Ningbo, ChinaDepartment of Cardiology, Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, ChinaClinical Medicine Research Centre for Cardiovascular Disease of Ningbo, Ningbo, ChinaBackground and aimsThe association between sleep traits and coronary artery disease (CAD) in patients with diabetes has been reported in previous observational studies. However, whether these potential relationships are causal remains unclear. We aim to assess the causal relationship between sleep traits and CAD in diabetic.MethodsGenetic instrumental variables associated with five sleep-related traits (insomnia, sleep duration, ease of getting up, morningness and snoring) were extracted from corresponding genome-wide association studies (GWAS). The associations of genetic variants with CAD were based on 15,666 individuals with diabetes (3,968 CAD cases and 11,696 controls). The primary analysis was derived using the inverse variance weighting method. Further sensitivity analysis was conducted to confirm the robustness and consistency of the main results.ResultsGenetic liability to insomnia was significantly related to the increased risk of CAD in individuals with diabetes [odds ratio (OR): 1.163; 95% CI: 1.072–1.254; p = 0.001]. Suggestive evidence was found for the borderline associations between both sleep duration (OR: 0.629; 95% CI: 0.380–1.042, p = 0.072) and snoring (OR: 1.010, 95% CI: 1.000–1.020, p = 0.050) with CAD risk. However, no consistent evidence was found for the association between ease of getting up and morningness with the risk of CAD in diabetic. Similar results can be verified in most sensitivity analyses.ConclusionsWe provide consistent evidence for the causal effect of insomnia on the increased risk of CAD in individuals with diabetes. The management of sleep health should be emphasized to prevent CAD in diabetic patients.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1132281/fullsleep traitscoronary artery diseasediabetescausal associationinsomnia |
| spellingShingle | Mengyun Tian Hongchuang Ma Hongchuang Ma Hongchuang Ma Jiaxi Shen Jiaxi Shen Teng Hu Hanbin Cui Hanbin Cui Hanbin Cui Ning Huangfu Ning Huangfu Ning Huangfu Causal association between sleep traits and the risk of coronary artery disease in patients with diabetes Frontiers in Cardiovascular Medicine sleep traits coronary artery disease diabetes causal association insomnia |
| title | Causal association between sleep traits and the risk of coronary artery disease in patients with diabetes |
| title_full | Causal association between sleep traits and the risk of coronary artery disease in patients with diabetes |
| title_fullStr | Causal association between sleep traits and the risk of coronary artery disease in patients with diabetes |
| title_full_unstemmed | Causal association between sleep traits and the risk of coronary artery disease in patients with diabetes |
| title_short | Causal association between sleep traits and the risk of coronary artery disease in patients with diabetes |
| title_sort | causal association between sleep traits and the risk of coronary artery disease in patients with diabetes |
| topic | sleep traits coronary artery disease diabetes causal association insomnia |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1132281/full |
| work_keys_str_mv | AT mengyuntian causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT hongchuangma causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT hongchuangma causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT hongchuangma causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT jiaxishen causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT jiaxishen causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT tenghu causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT hanbincui causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT hanbincui causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT hanbincui causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT ninghuangfu causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT ninghuangfu causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes AT ninghuangfu causalassociationbetweensleeptraitsandtheriskofcoronaryarterydiseaseinpatientswithdiabetes |