Clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging: Results from a multicenter observational cohort study by the Hokkaido Pancreatic Cancer Study Group (HOPS UR‐01)
Abstract Background and Aim Effective multidisciplinary approaches for unresectable pancreatic cancer (UR‐PC) that include modern chemotherapeutic regimens and subsequent conversion surgery (CS) are being developed. The aim of this study was to evaluate outcomes of patients clinically diagnosed with...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-09-01
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| Series: | Annals of Gastroenterological Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ags3.12272 |
| _version_ | 1818616988015001600 |
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| author | Yasutoshi Kimura Toru Nakamura Tsuyoshi Hayashi Masaki Kuwatani Masayo Motoya Makoto Yoshida Masafumi Imamura Minoru Nagayama Hiroshi Yamaguchi Keisuke Yamakita Takuma Goto Yusuke Sakuhara Kuniyuki Takahashi Hiroyuki Maguchi Satoshi Hirano Ichiro Takemasa |
| author_facet | Yasutoshi Kimura Toru Nakamura Tsuyoshi Hayashi Masaki Kuwatani Masayo Motoya Makoto Yoshida Masafumi Imamura Minoru Nagayama Hiroshi Yamaguchi Keisuke Yamakita Takuma Goto Yusuke Sakuhara Kuniyuki Takahashi Hiroyuki Maguchi Satoshi Hirano Ichiro Takemasa |
| author_sort | Yasutoshi Kimura |
| collection | DOAJ |
| description | Abstract Background and Aim Effective multidisciplinary approaches for unresectable pancreatic cancer (UR‐PC) that include modern chemotherapeutic regimens and subsequent conversion surgery (CS) are being developed. The aim of this study was to evaluate outcomes of patients clinically diagnosed with UR‐PC, focusing on the efficacy of CS. Methods Patients ineligible for two multicenter phase II studies conducted by the Hokkaido Pancreatic Cancer Study Group (HOPS) were recruited. Sequential treatment regimens, conversion to radical surgery, and overall survival (OS) were analyzed by multidetector computed tomography (MDCT)‐based UR factors. Univariate and multivariate analyses were performed to identify predictors of OS. Results Sixty‐six of 247 intended recruits for HOPS studies from October 2013 to April 2016 were included. Unresectability was due to locally advanced (LA) disease and metastasis (M) in 42 and 24 patients, respectively. Induction therapy began with chemotherapy (CT) and chemoradiotherapy (CRT) in 44 and 17 patients, respectively, of whom 23 received modern CT regimens. Radical surgery was completed in 12 (LA, 10; M, two) with a median treatment interval of 10.3 months (range, 2‐32). Eleven patients (91.6%) achieved pathological R0 resection. Median OS was significantly longer in patients who underwent CS than those who did not (44.1 vs 14.5 months, P < 0.0001). CS was an independent predictor of OS (hazard ratio, 0.078; 95% confident interval, 0.017‐0.348; P = 0.001). Conclusion Conversion surgery after a favorable response to sequential treatment might prolong survival in patients with UR‐PC. Precise diagnosis on MDCT followed by sequential multimodal anticancer treatment is essential. |
| first_indexed | 2024-12-16T16:58:32Z |
| format | Article |
| id | doaj.art-22208a636cd54d64861323ddb6ea2be9 |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-12-16T16:58:32Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-22208a636cd54d64861323ddb6ea2be92022-12-21T22:23:49ZengWileyAnnals of Gastroenterological Surgery2475-03282019-09-013552353310.1002/ags3.12272Clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging: Results from a multicenter observational cohort study by the Hokkaido Pancreatic Cancer Study Group (HOPS UR‐01)Yasutoshi Kimura0Toru Nakamura1Tsuyoshi Hayashi2Masaki Kuwatani3Masayo Motoya4Makoto Yoshida5Masafumi Imamura6Minoru Nagayama7Hiroshi Yamaguchi8Keisuke Yamakita9Takuma Goto10Yusuke Sakuhara11Kuniyuki Takahashi12Hiroyuki Maguchi13Satoshi Hirano14Ichiro Takemasa15Department of Surgery Surgical Oncology and Science Sapporo Medical University School of Medicine Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanDepartment of Surgery Surgical Oncology and Science Sapporo Medical University School of Medicine Sapporo JapanDepartment of Surgery Surgical Oncology and Science Sapporo Medical University School of Medicine Sapporo JapanDepartment of Surgery Surgical Oncology and Science Sapporo Medical University School of Medicine Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanHokkaido Pancreatic Cancer Study Group; HOPS Sapporo JapanDepartment of Surgery Surgical Oncology and Science Sapporo Medical University School of Medicine Sapporo JapanAbstract Background and Aim Effective multidisciplinary approaches for unresectable pancreatic cancer (UR‐PC) that include modern chemotherapeutic regimens and subsequent conversion surgery (CS) are being developed. The aim of this study was to evaluate outcomes of patients clinically diagnosed with UR‐PC, focusing on the efficacy of CS. Methods Patients ineligible for two multicenter phase II studies conducted by the Hokkaido Pancreatic Cancer Study Group (HOPS) were recruited. Sequential treatment regimens, conversion to radical surgery, and overall survival (OS) were analyzed by multidetector computed tomography (MDCT)‐based UR factors. Univariate and multivariate analyses were performed to identify predictors of OS. Results Sixty‐six of 247 intended recruits for HOPS studies from October 2013 to April 2016 were included. Unresectability was due to locally advanced (LA) disease and metastasis (M) in 42 and 24 patients, respectively. Induction therapy began with chemotherapy (CT) and chemoradiotherapy (CRT) in 44 and 17 patients, respectively, of whom 23 received modern CT regimens. Radical surgery was completed in 12 (LA, 10; M, two) with a median treatment interval of 10.3 months (range, 2‐32). Eleven patients (91.6%) achieved pathological R0 resection. Median OS was significantly longer in patients who underwent CS than those who did not (44.1 vs 14.5 months, P < 0.0001). CS was an independent predictor of OS (hazard ratio, 0.078; 95% confident interval, 0.017‐0.348; P = 0.001). Conclusion Conversion surgery after a favorable response to sequential treatment might prolong survival in patients with UR‐PC. Precise diagnosis on MDCT followed by sequential multimodal anticancer treatment is essential.https://doi.org/10.1002/ags3.12272locally advancedmetastaticmultidisciplinary treatmentradical surgeryunresectable pancreatic cancer |
| spellingShingle | Yasutoshi Kimura Toru Nakamura Tsuyoshi Hayashi Masaki Kuwatani Masayo Motoya Makoto Yoshida Masafumi Imamura Minoru Nagayama Hiroshi Yamaguchi Keisuke Yamakita Takuma Goto Yusuke Sakuhara Kuniyuki Takahashi Hiroyuki Maguchi Satoshi Hirano Ichiro Takemasa Clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging: Results from a multicenter observational cohort study by the Hokkaido Pancreatic Cancer Study Group (HOPS UR‐01) Annals of Gastroenterological Surgery locally advanced metastatic multidisciplinary treatment radical surgery unresectable pancreatic cancer |
| title | Clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging: Results from a multicenter observational cohort study by the Hokkaido Pancreatic Cancer Study Group (HOPS UR‐01) |
| title_full | Clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging: Results from a multicenter observational cohort study by the Hokkaido Pancreatic Cancer Study Group (HOPS UR‐01) |
| title_fullStr | Clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging: Results from a multicenter observational cohort study by the Hokkaido Pancreatic Cancer Study Group (HOPS UR‐01) |
| title_full_unstemmed | Clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging: Results from a multicenter observational cohort study by the Hokkaido Pancreatic Cancer Study Group (HOPS UR‐01) |
| title_short | Clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging: Results from a multicenter observational cohort study by the Hokkaido Pancreatic Cancer Study Group (HOPS UR‐01) |
| title_sort | clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging results from a multicenter observational cohort study by the hokkaido pancreatic cancer study group hops ur 01 |
| topic | locally advanced metastatic multidisciplinary treatment radical surgery unresectable pancreatic cancer |
| url | https://doi.org/10.1002/ags3.12272 |
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