Association of insulin resistance with polycystic ovary syndrome phenotypes and patients’ characteristics: a cross-sectional study in Iran
Abstract Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. This disorder affects 6–15% of women of childbearing age worldwide. It is diagnosed with hyperandrogenism, polycystic ovaries, and chronic anovulation with insulin resistance. This study aimed to ass...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12958-023-01160-z |
| _version_ | 1797451029497774080 |
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| author | Leili Rahmatnezhad Lida Moghaddam-Banaem Tahereh Behroozi-Lak Afshin Shiva Javad Rasouli |
| author_facet | Leili Rahmatnezhad Lida Moghaddam-Banaem Tahereh Behroozi-Lak Afshin Shiva Javad Rasouli |
| author_sort | Leili Rahmatnezhad |
| collection | DOAJ |
| description | Abstract Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. This disorder affects 6–15% of women of childbearing age worldwide. It is diagnosed with hyperandrogenism, polycystic ovaries, and chronic anovulation with insulin resistance. This study aimed to assess the prevalence of insulin resistance (IR) in 4 phenotypes of PCOS, and its relationship with demographic, clinical, and paraclinical individual characteristics in a sample of Iranian PCOS patients. Methods This particular cross-sectional investigation involved 160 female participants, aged between 18 and 45 years, who were receiving care at gynecology clinics in Urmia, northwestern Iran. All the participants had been diagnosed with PCOS and were categorized into one of four phenotypes. All the participants underwent clinical evaluations, paraclinical assessments, and ultrasound scans. IR was defined as HOMA-IR > 2.5. The statistical significance level was 0.05. Results Among the 160 participants, the prevalences of the 4 phenotypes were: A: 83 (51.9%), B: 37 (23.1%), C: 21 (13.1%), and D: 19 (11.9%). IR was detected in 119 participants (74.4%); its rate was significantly different between the 4 phenotypes (p-value: 0.008) as A: 62 (74.7%), B: 34 (91.9%), C: 12 (57.1%), D: 11 (57.9%). Linear and logistic regression analyses were performed to control confounding factors. In linear regression, PCOS phenotype, classic phenotype (A&B), economic status, and Hb levels were significantly related to HOMA-IR; in logistic regression Hb levels, exercise, economic status, and PCOS phenotypes were significantly associated with insulin resistance. Conclusions The most prevalent PCOS phenotype in this study was A. PCOS phenotypes were significantly related to insulin resistance and HOMA-IR, with the highest levels of insulin resistance and HOMA-IR observed in phenotype B. Determining the phenotype of PCOS may be helpful for better management of PCOS and its associated complications. However, further investigations are recommended in this regard. |
| first_indexed | 2024-03-09T14:48:04Z |
| format | Article |
| id | doaj.art-22220ab092334550a8933cd1623de917 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-03-09T14:48:04Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-22220ab092334550a8933cd1623de9172023-11-26T14:35:39ZengBMCReproductive Biology and Endocrinology1477-78272023-11-0121111110.1186/s12958-023-01160-zAssociation of insulin resistance with polycystic ovary syndrome phenotypes and patients’ characteristics: a cross-sectional study in IranLeili Rahmatnezhad0Lida Moghaddam-Banaem1Tahereh Behroozi-Lak2Afshin Shiva3Javad Rasouli4Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares UniversityReproductive Health Research Center, Urmia University of Medical SciencesExperimental and Applied Pharmaceutical Sciences Research Center, Urmia University of Medical SciencesDepartment of Epidemiology and Biostatistics, Faculty of Medicine, Urmia University of Medical SciencesAbstract Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. This disorder affects 6–15% of women of childbearing age worldwide. It is diagnosed with hyperandrogenism, polycystic ovaries, and chronic anovulation with insulin resistance. This study aimed to assess the prevalence of insulin resistance (IR) in 4 phenotypes of PCOS, and its relationship with demographic, clinical, and paraclinical individual characteristics in a sample of Iranian PCOS patients. Methods This particular cross-sectional investigation involved 160 female participants, aged between 18 and 45 years, who were receiving care at gynecology clinics in Urmia, northwestern Iran. All the participants had been diagnosed with PCOS and were categorized into one of four phenotypes. All the participants underwent clinical evaluations, paraclinical assessments, and ultrasound scans. IR was defined as HOMA-IR > 2.5. The statistical significance level was 0.05. Results Among the 160 participants, the prevalences of the 4 phenotypes were: A: 83 (51.9%), B: 37 (23.1%), C: 21 (13.1%), and D: 19 (11.9%). IR was detected in 119 participants (74.4%); its rate was significantly different between the 4 phenotypes (p-value: 0.008) as A: 62 (74.7%), B: 34 (91.9%), C: 12 (57.1%), D: 11 (57.9%). Linear and logistic regression analyses were performed to control confounding factors. In linear regression, PCOS phenotype, classic phenotype (A&B), economic status, and Hb levels were significantly related to HOMA-IR; in logistic regression Hb levels, exercise, economic status, and PCOS phenotypes were significantly associated with insulin resistance. Conclusions The most prevalent PCOS phenotype in this study was A. PCOS phenotypes were significantly related to insulin resistance and HOMA-IR, with the highest levels of insulin resistance and HOMA-IR observed in phenotype B. Determining the phenotype of PCOS may be helpful for better management of PCOS and its associated complications. However, further investigations are recommended in this regard.https://doi.org/10.1186/s12958-023-01160-zInsulin resistancePhenotypesPolycystic ovary syndromeHOMA-IR |
| spellingShingle | Leili Rahmatnezhad Lida Moghaddam-Banaem Tahereh Behroozi-Lak Afshin Shiva Javad Rasouli Association of insulin resistance with polycystic ovary syndrome phenotypes and patients’ characteristics: a cross-sectional study in Iran Reproductive Biology and Endocrinology Insulin resistance Phenotypes Polycystic ovary syndrome HOMA-IR |
| title | Association of insulin resistance with polycystic ovary syndrome phenotypes and patients’ characteristics: a cross-sectional study in Iran |
| title_full | Association of insulin resistance with polycystic ovary syndrome phenotypes and patients’ characteristics: a cross-sectional study in Iran |
| title_fullStr | Association of insulin resistance with polycystic ovary syndrome phenotypes and patients’ characteristics: a cross-sectional study in Iran |
| title_full_unstemmed | Association of insulin resistance with polycystic ovary syndrome phenotypes and patients’ characteristics: a cross-sectional study in Iran |
| title_short | Association of insulin resistance with polycystic ovary syndrome phenotypes and patients’ characteristics: a cross-sectional study in Iran |
| title_sort | association of insulin resistance with polycystic ovary syndrome phenotypes and patients characteristics a cross sectional study in iran |
| topic | Insulin resistance Phenotypes Polycystic ovary syndrome HOMA-IR |
| url | https://doi.org/10.1186/s12958-023-01160-z |
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