Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers
Biliary tract cancers (BTCs), including cholangiocarcinoma and gallbladder carcinoma, originate from the biliary epithelium and have a poor prognosis. Surgery is the only choice for cure in the early stage of disease. However, most patients are diagnosed in the advanced stage and lose the chance for...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1049812/full |
| _version_ | 1811257546175938560 |
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| author | Yun-cheng Li Kang-shuai Li Zeng-li Liu Yong-chang Tang Xiao-Qiang Hu Xing-yong Li An-da Shi Li-ming Zhao Li-Zhuang Shu Shuo Lian Zhang-di Yan Shao-hui Huang Guo-li Sheng Yan Song Yun-jia Liu Fan Huan Ming-hui Zhang Zong-li Zhang |
| author_facet | Yun-cheng Li Kang-shuai Li Zeng-li Liu Yong-chang Tang Xiao-Qiang Hu Xing-yong Li An-da Shi Li-ming Zhao Li-Zhuang Shu Shuo Lian Zhang-di Yan Shao-hui Huang Guo-li Sheng Yan Song Yun-jia Liu Fan Huan Ming-hui Zhang Zong-li Zhang |
| author_sort | Yun-cheng Li |
| collection | DOAJ |
| description | Biliary tract cancers (BTCs), including cholangiocarcinoma and gallbladder carcinoma, originate from the biliary epithelium and have a poor prognosis. Surgery is the only choice for cure in the early stage of disease. However, most patients are diagnosed in the advanced stage and lose the chance for surgery. Early diagnosis could significantly improve the prognosis of patients. Bile has complex components and is in direct contact with biliary tract tumors. Bile components are closely related to the occurrence and development of biliary tract tumors and may be applied as biomarkers for BTCs. Meanwhile, arising evidence has confirmed the immunoregulatory role of bile components. In this review, we aim to summarize and discuss the relationship between bile components and biliary tract cancers and their ability as biomarkers for BTCs, highlighting the role of bile components in regulating immune response, and their promising application prospects. |
| first_indexed | 2024-04-12T17:59:05Z |
| format | Article |
| id | doaj.art-2223e087bbcf4446aa7db24be56c49b0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T17:59:05Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2223e087bbcf4446aa7db24be56c49b02022-12-22T03:22:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.10498121049812Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancersYun-cheng LiKang-shuai LiZeng-li LiuYong-chang TangXiao-Qiang HuXing-yong LiAn-da ShiLi-ming ZhaoLi-Zhuang ShuShuo LianZhang-di YanShao-hui HuangGuo-li ShengYan SongYun-jia LiuFan HuanMing-hui ZhangZong-li ZhangBiliary tract cancers (BTCs), including cholangiocarcinoma and gallbladder carcinoma, originate from the biliary epithelium and have a poor prognosis. Surgery is the only choice for cure in the early stage of disease. However, most patients are diagnosed in the advanced stage and lose the chance for surgery. Early diagnosis could significantly improve the prognosis of patients. Bile has complex components and is in direct contact with biliary tract tumors. Bile components are closely related to the occurrence and development of biliary tract tumors and may be applied as biomarkers for BTCs. Meanwhile, arising evidence has confirmed the immunoregulatory role of bile components. In this review, we aim to summarize and discuss the relationship between bile components and biliary tract cancers and their ability as biomarkers for BTCs, highlighting the role of bile components in regulating immune response, and their promising application prospects.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1049812/fullbiliary tract cancersbile componentsbiomarkersimmune effectliquid biopsy |
| spellingShingle | Yun-cheng Li Kang-shuai Li Zeng-li Liu Yong-chang Tang Xiao-Qiang Hu Xing-yong Li An-da Shi Li-ming Zhao Li-Zhuang Shu Shuo Lian Zhang-di Yan Shao-hui Huang Guo-li Sheng Yan Song Yun-jia Liu Fan Huan Ming-hui Zhang Zong-li Zhang Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers Frontiers in Immunology biliary tract cancers bile components biomarkers immune effect liquid biopsy |
| title | Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers |
| title_full | Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers |
| title_fullStr | Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers |
| title_full_unstemmed | Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers |
| title_short | Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers |
| title_sort | research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers |
| topic | biliary tract cancers bile components biomarkers immune effect liquid biopsy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1049812/full |
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