The Predictive Value of First and Second Trimester Screening Test Biomarkers in Preeclampsia
Objective: This study aimed to determine the predictive value of first and second trimester screening test biomarkers in preeclampsia. Methods: This was a retrospective case-control study. While 85 patients diagnosed with pre-eclampsia between January 2013-December 2016 constituted the study group,...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-04-01
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| Series: | Forbes Tıp Dergisi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=forbes&un=FJM-20982 |
| _version_ | 1797767511231430656 |
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| author | Zeynep ATAMAN YILDIRIM Duygu TUĞRUL ERSAK Burcu TİMUR Serkan KAHYAOĞLU |
| author_facet | Zeynep ATAMAN YILDIRIM Duygu TUĞRUL ERSAK Burcu TİMUR Serkan KAHYAOĞLU |
| author_sort | Zeynep ATAMAN YILDIRIM |
| collection | DOAJ |
| description | Objective: This study aimed to determine the predictive value of first and second trimester screening test biomarkers in preeclampsia.
Methods: This was a retrospective case-control study. While 85 patients diagnosed with pre-eclampsia between January 2013-December 2016 constituted the study group, randomly assigned 93 patients with no additional obstetric problems constituted the control group. Demographic characteristics, laboratory results, obstetric outcomes, first and second trimester screening test results were collected from the hospital records.
Results: Of the 85 preeclamptic patients, 32 had mild, 53 had severe pre-eclampsia. When the preeclampsia group was compared with the control group, the low level of pregnancy associated plasma protein-A (PAPP-A) multiples of median (MoM), the high level of human chorionic gonadotropin (hCG) MoM and nuchal translucency (NT) MoM was found to be statistically significant. However, these markers have not been found to be clinically useful for the mild preeclampsia group compared with the severe preeclampsia group. A ROC curve was drawn to show the predictive role of NT MoM, hCG MoM and PAPP-A MoM for preeclampsia. The area under the curve (AUC) was 0.628+-0.042 [p=0.003; 95% confidence interval (CI): 0.545-0.711] for NT MoM and 0.697+-0.047 (p<0.001; 95% CI: 0.605-0.789) for hCG MoM. The AUC was 0.589+-0.044 (p=0.040; 95% CI: 0.503-0.676) for PAPP-A MoM. These results indicate that there were significant relationships between these variables and pre-eclampsia.
Conclusion: Low levels of PAPP-A MoM, high levels of hCG MoM and NT MoM are useful significant predictive markers for prediction of preeclampsia. |
| first_indexed | 2024-03-12T20:39:59Z |
| format | Article |
| id | doaj.art-2225978b3a4a4531a0b067f601d5d7f3 |
| institution | Directory Open Access Journal |
| issn | 2757-5241 |
| language | English |
| last_indexed | 2024-03-12T20:39:59Z |
| publishDate | 2022-04-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Forbes Tıp Dergisi |
| spelling | doaj.art-2225978b3a4a4531a0b067f601d5d7f32023-08-01T10:46:53ZengGalenos YayineviForbes Tıp Dergisi2757-52412022-04-0131687410.4274/forbes.galenos.2022.20982FJM-20982The Predictive Value of First and Second Trimester Screening Test Biomarkers in PreeclampsiaZeynep ATAMAN YILDIRIM0Duygu TUĞRUL ERSAK1Burcu TİMUR2Serkan KAHYAOĞLU3Zekai Tahir Burak Women Health Care Training and Research Hospital, Clinic of Obstetrics and Gynecology, Ankara, TurkeyZekai Tahir Burak Women Health Care Training and Research Hospital, Clinic of Obstetrics and Gynecology, Ankara, TurkeyOrdu University Training and Research Hospital, Department of Obstetrics and Gynecology, Ordu, TurkeyZekai Tahir Burak Women Health Care Training and Research Hospital, Clinic of Obstetrics and Gynecology, Ankara, TurkeyObjective: This study aimed to determine the predictive value of first and second trimester screening test biomarkers in preeclampsia. Methods: This was a retrospective case-control study. While 85 patients diagnosed with pre-eclampsia between January 2013-December 2016 constituted the study group, randomly assigned 93 patients with no additional obstetric problems constituted the control group. Demographic characteristics, laboratory results, obstetric outcomes, first and second trimester screening test results were collected from the hospital records. Results: Of the 85 preeclamptic patients, 32 had mild, 53 had severe pre-eclampsia. When the preeclampsia group was compared with the control group, the low level of pregnancy associated plasma protein-A (PAPP-A) multiples of median (MoM), the high level of human chorionic gonadotropin (hCG) MoM and nuchal translucency (NT) MoM was found to be statistically significant. However, these markers have not been found to be clinically useful for the mild preeclampsia group compared with the severe preeclampsia group. A ROC curve was drawn to show the predictive role of NT MoM, hCG MoM and PAPP-A MoM for preeclampsia. The area under the curve (AUC) was 0.628+-0.042 [p=0.003; 95% confidence interval (CI): 0.545-0.711] for NT MoM and 0.697+-0.047 (p<0.001; 95% CI: 0.605-0.789) for hCG MoM. The AUC was 0.589+-0.044 (p=0.040; 95% CI: 0.503-0.676) for PAPP-A MoM. These results indicate that there were significant relationships between these variables and pre-eclampsia. Conclusion: Low levels of PAPP-A MoM, high levels of hCG MoM and NT MoM are useful significant predictive markers for prediction of preeclampsia.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=forbes&un=FJM-20982pre-eclampsiaprenatal screeningmaternal serum tests |
| spellingShingle | Zeynep ATAMAN YILDIRIM Duygu TUĞRUL ERSAK Burcu TİMUR Serkan KAHYAOĞLU The Predictive Value of First and Second Trimester Screening Test Biomarkers in Preeclampsia Forbes Tıp Dergisi pre-eclampsia prenatal screening maternal serum tests |
| title | The Predictive Value of First and Second Trimester Screening Test Biomarkers in Preeclampsia |
| title_full | The Predictive Value of First and Second Trimester Screening Test Biomarkers in Preeclampsia |
| title_fullStr | The Predictive Value of First and Second Trimester Screening Test Biomarkers in Preeclampsia |
| title_full_unstemmed | The Predictive Value of First and Second Trimester Screening Test Biomarkers in Preeclampsia |
| title_short | The Predictive Value of First and Second Trimester Screening Test Biomarkers in Preeclampsia |
| title_sort | predictive value of first and second trimester screening test biomarkers in preeclampsia |
| topic | pre-eclampsia prenatal screening maternal serum tests |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=forbes&un=FJM-20982 |
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