Inhibition of Glutamine Uptake Resensitizes Paclitaxel Resistance in SKOV3-TR Ovarian Cancer Cell via mTORC1/S6K Signaling Pathway

Inhibition of Glutamine Uptake Resensitizes Paclitaxel Resistance in SKOV3-TR Ovarian Cancer Cell via mTORC1/S6K Signaling Pathway

Ovarian cancer is a carcinoma that affects women and that has a high mortality rate. Overcoming paclitaxel resistance is important for clinical application. However, the effect of amino acid metabolism regulation on paclitaxel-resistant ovarian cancer is still unknown. In this study, the effect of a...

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Bibliographic Details
Main Authors: Gyeongmi Kim, Se-Kyeong Jang, Yu Jin Kim, Hyeon-Ok Jin, Seunghee Bae, Jungil Hong, In-Chul Park, Jae Ho Lee
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
ovarian cancer
chemoresistance
glutamine uptake
metabolic reprogramming
ASCT2
mTORC1
Online Access:https://www.mdpi.com/1422-0067/23/15/8761

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