A Novel Biomimetic Magnetosensor Based on Magneto‐Optically Involved Conformational Variation of MagR/Cry4 Complex
Abstract During billions of years of evolution, some species develop fantastic magneto‐perception, offering a biomimetic route to develop the next generation of magneto‐sensors. Recently, a novel principle was proposed to explain the navigation of pigeons in the presence of geomagnetic fields and su...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2020-04-01
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| Series: | Advanced Electronic Materials |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/aelm.201901168 |
| _version_ | 1797656101378850816 |
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| author | Le Xue Tao Hu Zhen Guo Celi Yang Zhuoqing Wang Siying Qin Peilin Yang Can Xie Jian Xu Nuan Li Yanfei Shen Hui Jiang Dawei Deng Ning Gu Jianfei Sun |
| author_facet | Le Xue Tao Hu Zhen Guo Celi Yang Zhuoqing Wang Siying Qin Peilin Yang Can Xie Jian Xu Nuan Li Yanfei Shen Hui Jiang Dawei Deng Ning Gu Jianfei Sun |
| author_sort | Le Xue |
| collection | DOAJ |
| description | Abstract During billions of years of evolution, some species develop fantastic magneto‐perception, offering a biomimetic route to develop the next generation of magneto‐sensors. Recently, a novel principle was proposed to explain the navigation of pigeons in the presence of geomagnetic fields and sunlight. The key link is thought to lie in the magneto‐optically involved conformational variation of magnetoreceptor protein (MagR)/cryptochrome (Cry4) complex. The MagR/Cry4 complex is fabricated and purified in vitro, creating a magneto‐sensing device by immobilization of this protein on a graphene‐modified electrochemical electrode. By using electrochemical impedance spectroscopy, magneto‐sensing with a current detectability of 10 mT is realized with MagR/Cry4 complex. It is proved that this process requires the involvement of both magnetic fields and light, partly confirming in vitro the magneto‐perceptive mechanism of MagR/Cry4 complex. It is also shows that this device can be used to reflect the anisotropic responses of nanomaterials to the external magnetic field. It is believed this protein‐based magneto‐sensing will greatly boost development of bioelectronics and deepen understanding of the phenomena of magneto‐perception for organisms. |
| first_indexed | 2024-03-11T17:24:29Z |
| format | Article |
| id | doaj.art-22276ea1299b4e21b73a9fb40002df30 |
| institution | Directory Open Access Journal |
| issn | 2199-160X |
| language | English |
| last_indexed | 2024-03-11T17:24:29Z |
| publishDate | 2020-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Electronic Materials |
| spelling | doaj.art-22276ea1299b4e21b73a9fb40002df302023-10-19T05:02:13ZengWiley-VCHAdvanced Electronic Materials2199-160X2020-04-0164n/an/a10.1002/aelm.201901168A Novel Biomimetic Magnetosensor Based on Magneto‐Optically Involved Conformational Variation of MagR/Cry4 ComplexLe Xue0Tao Hu1Zhen Guo2Celi Yang3Zhuoqing Wang4Siying Qin5Peilin Yang6Can Xie7Jian Xu8Nuan Li9Yanfei Shen10Hui Jiang11Dawei Deng12Ning Gu13Jianfei Sun14Jiangsu Key Laboratory of Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing 210009 P. R. ChinaSchool of Mechanic Engineering Southeast University Nanjing 211189 P. R. ChinaState Key Laboratory of Membrane Biology Laboratory of Molecular Biophysics School of Life Sciences Peking University Beijing 100871 P. R. ChinaState Key Laboratory of Membrane Biology Laboratory of Molecular Biophysics School of Life Sciences Peking University Beijing 100871 P. R. ChinaState Key Laboratory of Membrane Biology Laboratory of Molecular Biophysics School of Life Sciences Peking University Beijing 100871 P. R. ChinaState Key Laboratory of Membrane Biology Laboratory of Molecular Biophysics School of Life Sciences Peking University Beijing 100871 P. R. ChinaState Key Laboratory of Membrane Biology Laboratory of Molecular Biophysics School of Life Sciences Peking University Beijing 100871 P. R. ChinaState Key Laboratory of Membrane Biology Laboratory of Molecular Biophysics School of Life Sciences Peking University Beijing 100871 P. R. ChinaSchool of Mechanic Engineering Southeast University Nanjing 211189 P. R. ChinaJiangsu Key Laboratory of Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing 210009 P. R. ChinaDepartment of Bioengineering School of Medicine Southeast University Nanjing 210009 P. R. ChinaState Key Laboratory of Bioelectronics Southeast University Nanjing 210096 P. R. ChinaDepartment of Biomedical Engineering School of Engineering China Pharmaceutical University Nanjing 210009 P. R. ChinaJiangsu Key Laboratory of Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing 210009 P. R. ChinaJiangsu Key Laboratory of Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing 210009 P. R. ChinaAbstract During billions of years of evolution, some species develop fantastic magneto‐perception, offering a biomimetic route to develop the next generation of magneto‐sensors. Recently, a novel principle was proposed to explain the navigation of pigeons in the presence of geomagnetic fields and sunlight. The key link is thought to lie in the magneto‐optically involved conformational variation of magnetoreceptor protein (MagR)/cryptochrome (Cry4) complex. The MagR/Cry4 complex is fabricated and purified in vitro, creating a magneto‐sensing device by immobilization of this protein on a graphene‐modified electrochemical electrode. By using electrochemical impedance spectroscopy, magneto‐sensing with a current detectability of 10 mT is realized with MagR/Cry4 complex. It is proved that this process requires the involvement of both magnetic fields and light, partly confirming in vitro the magneto‐perceptive mechanism of MagR/Cry4 complex. It is also shows that this device can be used to reflect the anisotropic responses of nanomaterials to the external magnetic field. It is believed this protein‐based magneto‐sensing will greatly boost development of bioelectronics and deepen understanding of the phenomena of magneto‐perception for organisms.https://doi.org/10.1002/aelm.201901168bioelectronicsmagneto‐sensingMagR proteinsMagR/Cry4 complex |
| spellingShingle | Le Xue Tao Hu Zhen Guo Celi Yang Zhuoqing Wang Siying Qin Peilin Yang Can Xie Jian Xu Nuan Li Yanfei Shen Hui Jiang Dawei Deng Ning Gu Jianfei Sun A Novel Biomimetic Magnetosensor Based on Magneto‐Optically Involved Conformational Variation of MagR/Cry4 Complex Advanced Electronic Materials bioelectronics magneto‐sensing MagR proteins MagR/Cry4 complex |
| title | A Novel Biomimetic Magnetosensor Based on Magneto‐Optically Involved Conformational Variation of MagR/Cry4 Complex |
| title_full | A Novel Biomimetic Magnetosensor Based on Magneto‐Optically Involved Conformational Variation of MagR/Cry4 Complex |
| title_fullStr | A Novel Biomimetic Magnetosensor Based on Magneto‐Optically Involved Conformational Variation of MagR/Cry4 Complex |
| title_full_unstemmed | A Novel Biomimetic Magnetosensor Based on Magneto‐Optically Involved Conformational Variation of MagR/Cry4 Complex |
| title_short | A Novel Biomimetic Magnetosensor Based on Magneto‐Optically Involved Conformational Variation of MagR/Cry4 Complex |
| title_sort | novel biomimetic magnetosensor based on magneto optically involved conformational variation of magr cry4 complex |
| topic | bioelectronics magneto‐sensing MagR proteins MagR/Cry4 complex |
| url | https://doi.org/10.1002/aelm.201901168 |
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