Simultaneous Determination of Seven Lipophilic and Hydrophilic Components in <i>Salvia miltiorrhiza</i> Bunge by LC-MS/MS Method and Its Application to a Transport Study in a Blood-Brain-Barrier Cell Model

Simultaneous Determination of Seven Lipophilic and Hydrophilic Components in <i>Salvia miltiorrhiza</i> Bunge by LC-MS/MS Method and Its Application to a Transport Study in a Blood-Brain-Barrier Cell Model

<i>Salvia miltiorrhiza</i> Bunge (SM) has been extensively used in Alzheimer’s disease treatment, the permeability through the blood-brain barrier (BBB) determining its efficacy. However, the transport mechanism of SM components across the BBB remains to be clarified. A simple, precise,...

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Bibliographic Details
Main Authors: Hui Wang, Mingyong Zhang, Jiahao Fang, Yuzhen He, Min Liu, Zhanying Hong, Yifeng Chai
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
<i>Salvia miltiorrhiza</i> Bunge
LC-MS/MS
active components
transmembrane transport
BBB cell model
Online Access:https://www.mdpi.com/1420-3049/27/3/657

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