Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease
The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from un...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336874/?tool=EBI |
| _version_ | 1818737679908470784 |
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| author | Melanie Ricke-Hoch Elisabeth Stelling Lisa Lasswitz Antonia P. Gunesch Martina Kasten Francisco J. Zapatero-Belinchón Graham Brogden Gisa Gerold Thomas Pietschmann Virginie Montiel Jean-Luc Balligand Federica Facciotti Emilio Hirsch Thomas Gausepohl Husni Elbahesh Guus F. Rimmelzwaan Anne Höfer Mark P. Kühnel Danny Jonigk Julian Eigendorf Uwe Tegtbur Lena Mink Michaela Scherr Thomas Illig Axel Schambach Tobias J. Pfeffer Andres Hilfiker Axel Haverich Denise Hilfiker-Kleiner |
| author_facet | Melanie Ricke-Hoch Elisabeth Stelling Lisa Lasswitz Antonia P. Gunesch Martina Kasten Francisco J. Zapatero-Belinchón Graham Brogden Gisa Gerold Thomas Pietschmann Virginie Montiel Jean-Luc Balligand Federica Facciotti Emilio Hirsch Thomas Gausepohl Husni Elbahesh Guus F. Rimmelzwaan Anne Höfer Mark P. Kühnel Danny Jonigk Julian Eigendorf Uwe Tegtbur Lena Mink Michaela Scherr Thomas Illig Axel Schambach Tobias J. Pfeffer Andres Hilfiker Axel Haverich Denise Hilfiker-Kleiner |
| author_sort | Melanie Ricke-Hoch |
| collection | DOAJ |
| description | The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses. |
| first_indexed | 2024-12-18T00:56:53Z |
| format | Article |
| id | doaj.art-2229a694ec8a40d4ab4e27c79d308d6b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T00:56:53Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2229a694ec8a40d4ab4e27c79d308d6b2022-12-21T21:26:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01168Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 diseaseMelanie Ricke-HochElisabeth StellingLisa LasswitzAntonia P. GuneschMartina KastenFrancisco J. Zapatero-BelinchónGraham BrogdenGisa GeroldThomas PietschmannVirginie MontielJean-Luc BalligandFederica FacciottiEmilio HirschThomas GausepohlHusni ElbaheshGuus F. RimmelzwaanAnne HöferMark P. KühnelDanny JonigkJulian EigendorfUwe TegtburLena MinkMichaela ScherrThomas IlligAxel SchambachTobias J. PfefferAndres HilfikerAxel HaverichDenise Hilfiker-KleinerThe SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336874/?tool=EBI |
| spellingShingle | Melanie Ricke-Hoch Elisabeth Stelling Lisa Lasswitz Antonia P. Gunesch Martina Kasten Francisco J. Zapatero-Belinchón Graham Brogden Gisa Gerold Thomas Pietschmann Virginie Montiel Jean-Luc Balligand Federica Facciotti Emilio Hirsch Thomas Gausepohl Husni Elbahesh Guus F. Rimmelzwaan Anne Höfer Mark P. Kühnel Danny Jonigk Julian Eigendorf Uwe Tegtbur Lena Mink Michaela Scherr Thomas Illig Axel Schambach Tobias J. Pfeffer Andres Hilfiker Axel Haverich Denise Hilfiker-Kleiner Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease PLoS ONE |
| title | Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease |
| title_full | Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease |
| title_fullStr | Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease |
| title_full_unstemmed | Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease |
| title_short | Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease |
| title_sort | impaired immune response mediated by prostaglandin e2 promotes severe covid 19 disease |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336874/?tool=EBI |
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