Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel.

Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel.

Hibernating animals develop fatty liver when active in summertime and undergo a switch to a fat oxidation state in the winter. We hypothesized that this switch might be determined by AMP and the dominance of opposing effects: metabolism through AMP deaminase (AMPD2) (summer) and activation of AMP-ac...

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Bibliographic Details
Main Authors: Miguel A Lanaspa, L Elaine Epperson, Nanxing Li, Christina Cicerchi, Gabriela E Garcia, Carlos A Roncal-Jimenez, Jessica Trostel, Swati Jain, Colin T Mant, Christopher J Rivard, Takuji Ishimoto, Michiko Shimada, Laura Gabriela Sanchez-Lozada, Takahiko Nakagawa, Alkesh Jani, Peter Stenvinkel, Sandra L Martin, Richard J Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4391924?pdf=render

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