Activation of Cdc42 is necessary for sustained oscillations of Ca2+ and PIP2 stimulated by antigen in RBL mast cells

Activation of Cdc42 is necessary for sustained oscillations of Ca2+ and PIP2 stimulated by antigen in RBL mast cells

Antigen stimulation of mast cells via FcεRI, the high-affinity receptor for IgE, triggers a signaling cascade that requires Ca2+ mobilization for exocytosis of secretory granules during the allergic response. To characterize the role of Rho GTPases in FcεRI signaling, we utilized a mutant RBL cell l...

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Bibliographic Details
Main Authors: Marcus M. Wilkes, Joshua D. Wilson, Barbara Baird, David Holowka
Format: Article
Language:English
Published: The Company of Biologists 2014-07-01
Series:Biology Open
Subjects:
Rho family proteins
FcεRI
Ca2+ signaling
Online Access:http://bio.biologists.org/content/3/8/700

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