Klotho Levels and Their Relationship with Inflammation and Survival among Alcoholic Patients
α-Klotho (Klotho) is an antiaging hormone with anti-inflammatory and antioxidative properties. Some studies suggest that Klotho increases in response to enhanced oxidative damage and inflammation. Alcoholism is a proinflammatory condition. The aim of this study was to analyze the relationship betwee...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/8/1151 |
| _version_ | 1827618050112749568 |
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| author | Candelaria Martín-González Elisa Espelosín-Ortega Pedro Abreu-González Camino Fernández-Rodríguez Víctor Eugenio Vera-Delgado Lourdes González-Navarrete Alen García-Rodríguez Antonio Martínez Riera Emilio González-Reimers |
| author_facet | Candelaria Martín-González Elisa Espelosín-Ortega Pedro Abreu-González Camino Fernández-Rodríguez Víctor Eugenio Vera-Delgado Lourdes González-Navarrete Alen García-Rodríguez Antonio Martínez Riera Emilio González-Reimers |
| author_sort | Candelaria Martín-González |
| collection | DOAJ |
| description | α-Klotho (Klotho) is an antiaging hormone with anti-inflammatory and antioxidative properties. Some studies suggest that Klotho increases in response to enhanced oxidative damage and inflammation. Alcoholism is a proinflammatory condition. The aim of this study was to analyze the relationship between Klotho and the serum levels of the inflammatory markers in alcoholic liver disease and to assess its prognostic value. We included 184 alcoholics and 35 age- and sex-matched controls. We determined the serum levels of Klotho, the tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8, and malondialdehyde (MDA), and routine laboratory variables. Patients were followed-up with during 16 ± 18 months; 67 patients died. Klotho levels were higher among cirrhotics (with KW = 37.00 and <i>p</i> < 0.001) and were related to the Child–Pugh score (with KW = 15.96 and <i>p</i> < 0.001) and to the TNF-α (ρ = 0.28; <i>p</i> < 0.001) and MDA (ρ = 0.21; <i>p</i> = 0.006). The child’s groups were associated with mortality, both in the univariate (with the log-rank = 13.56, <i>p</i> = 0.001, Breslow = 12.33, and <i>p</i> = 0.002) and multivariate (with β = 0.43, <i>p</i> = 0.02, and OR = 1.53 (1.07–2.15)) analyses, also introducing Klotho and the TNF-α as dichotomic variables. However, the independent prognostic value of the Child’s groups was displaced by Klotho when only cirrhotics were considered; Klotho, over the median (574.4 pg/mL), was associated with higher mortality (with <i>p</i> = 0.04 and OR = 2.68 (1.06–6.84)). We conclude that Klotho is increased in liver cirrhosis. It is directly related to TNF-α, MDA, and to mortality in cirrhotics. |
| first_indexed | 2024-03-09T10:00:10Z |
| format | Article |
| id | doaj.art-222fed0f11de49a890df2334a87f1254 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T10:00:10Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-222fed0f11de49a890df2334a87f12542023-12-01T23:29:25ZengMDPI AGBiomolecules2218-273X2022-08-01128115110.3390/biom12081151Klotho Levels and Their Relationship with Inflammation and Survival among Alcoholic PatientsCandelaria Martín-González0Elisa Espelosín-Ortega1Pedro Abreu-González2Camino Fernández-Rodríguez3Víctor Eugenio Vera-Delgado4Lourdes González-Navarrete5Alen García-Rodríguez6Antonio Martínez Riera7Emilio González-Reimers8Departamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainServicio de Laboratorio, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Ciencias Médicas Básicas, Unidad de Fisiología, Universidad de la Laguna, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, Spainα-Klotho (Klotho) is an antiaging hormone with anti-inflammatory and antioxidative properties. Some studies suggest that Klotho increases in response to enhanced oxidative damage and inflammation. Alcoholism is a proinflammatory condition. The aim of this study was to analyze the relationship between Klotho and the serum levels of the inflammatory markers in alcoholic liver disease and to assess its prognostic value. We included 184 alcoholics and 35 age- and sex-matched controls. We determined the serum levels of Klotho, the tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8, and malondialdehyde (MDA), and routine laboratory variables. Patients were followed-up with during 16 ± 18 months; 67 patients died. Klotho levels were higher among cirrhotics (with KW = 37.00 and <i>p</i> < 0.001) and were related to the Child–Pugh score (with KW = 15.96 and <i>p</i> < 0.001) and to the TNF-α (ρ = 0.28; <i>p</i> < 0.001) and MDA (ρ = 0.21; <i>p</i> = 0.006). The child’s groups were associated with mortality, both in the univariate (with the log-rank = 13.56, <i>p</i> = 0.001, Breslow = 12.33, and <i>p</i> = 0.002) and multivariate (with β = 0.43, <i>p</i> = 0.02, and OR = 1.53 (1.07–2.15)) analyses, also introducing Klotho and the TNF-α as dichotomic variables. However, the independent prognostic value of the Child’s groups was displaced by Klotho when only cirrhotics were considered; Klotho, over the median (574.4 pg/mL), was associated with higher mortality (with <i>p</i> = 0.04 and OR = 2.68 (1.06–6.84)). We conclude that Klotho is increased in liver cirrhosis. It is directly related to TNF-α, MDA, and to mortality in cirrhotics.https://www.mdpi.com/2218-273X/12/8/1151alpha-Klothocirrhosisprognosisinflammationlipid peroxidation |
| spellingShingle | Candelaria Martín-González Elisa Espelosín-Ortega Pedro Abreu-González Camino Fernández-Rodríguez Víctor Eugenio Vera-Delgado Lourdes González-Navarrete Alen García-Rodríguez Antonio Martínez Riera Emilio González-Reimers Klotho Levels and Their Relationship with Inflammation and Survival among Alcoholic Patients Biomolecules alpha-Klotho cirrhosis prognosis inflammation lipid peroxidation |
| title | Klotho Levels and Their Relationship with Inflammation and Survival among Alcoholic Patients |
| title_full | Klotho Levels and Their Relationship with Inflammation and Survival among Alcoholic Patients |
| title_fullStr | Klotho Levels and Their Relationship with Inflammation and Survival among Alcoholic Patients |
| title_full_unstemmed | Klotho Levels and Their Relationship with Inflammation and Survival among Alcoholic Patients |
| title_short | Klotho Levels and Their Relationship with Inflammation and Survival among Alcoholic Patients |
| title_sort | klotho levels and their relationship with inflammation and survival among alcoholic patients |
| topic | alpha-Klotho cirrhosis prognosis inflammation lipid peroxidation |
| url | https://www.mdpi.com/2218-273X/12/8/1151 |
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