O papel da leptina na regulação da homeostasia energética.
As a growing number of people suffer from obesity, understanding the mechanisms by which various hormones and neurotransmitters have influence on energy balance has been the subject of intensive research. Recent experimental studies have implicated leptin as a crucial controller of body weight. Lept...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
2009-06-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1694 |
| _version_ | 1811242485881503744 |
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| author | Mónica Sousa Carmen Brás-Silva Adelino Leite-Moreira |
| author_facet | Mónica Sousa Carmen Brás-Silva Adelino Leite-Moreira |
| author_sort | Mónica Sousa |
| collection | DOAJ |
| description | As a growing number of people suffer from obesity, understanding the mechanisms by which various hormones and neurotransmitters have influence on energy balance has been the subject of intensive research. Recent experimental studies have implicated leptin as a crucial controller of body weight. Leptin is a 167-aminoacid peptide hormone, which is mainly produced by adipocytes, and its levels in the circulation are increased in proportion to fat mass. Circulating leptin conveys information to the hypothalamus regarding the amount of energy stored in adipose tissue, suppressing appetite and affecting energy expenditure. Considerable evidence shows that this hormone is also involved in the regulation of several physiological processes such as reproduction, angiogenesis, immunity, hematopoiesis and bone remodelling. Leptin acts through leptin receptors that are ubiquitously distributed and hence explain the pleiotropic roles of leptin. In the present review, we will summarize the recent developments in the leptin field, with particular attention to aspects related with physiological and molecular mechanisms regulating energy homeostasis, as well as their implications in the pathophysiology of weight disorders. |
| first_indexed | 2024-04-12T13:51:52Z |
| format | Article |
| id | doaj.art-2230099ed2bc4ea9bfb2a61b2dbfda9f |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T13:51:52Z |
| publishDate | 2009-06-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-2230099ed2bc4ea9bfb2a61b2dbfda9f2022-12-22T03:30:30ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582009-06-0122310.20344/amp.1694O papel da leptina na regulação da homeostasia energética.Mónica Sousa0Carmen Brás-SilvaAdelino Leite-MoreiraUniversidade do Porto, Porto.As a growing number of people suffer from obesity, understanding the mechanisms by which various hormones and neurotransmitters have influence on energy balance has been the subject of intensive research. Recent experimental studies have implicated leptin as a crucial controller of body weight. Leptin is a 167-aminoacid peptide hormone, which is mainly produced by adipocytes, and its levels in the circulation are increased in proportion to fat mass. Circulating leptin conveys information to the hypothalamus regarding the amount of energy stored in adipose tissue, suppressing appetite and affecting energy expenditure. Considerable evidence shows that this hormone is also involved in the regulation of several physiological processes such as reproduction, angiogenesis, immunity, hematopoiesis and bone remodelling. Leptin acts through leptin receptors that are ubiquitously distributed and hence explain the pleiotropic roles of leptin. In the present review, we will summarize the recent developments in the leptin field, with particular attention to aspects related with physiological and molecular mechanisms regulating energy homeostasis, as well as their implications in the pathophysiology of weight disorders.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1694 |
| spellingShingle | Mónica Sousa Carmen Brás-Silva Adelino Leite-Moreira O papel da leptina na regulação da homeostasia energética. Acta Médica Portuguesa |
| title | O papel da leptina na regulação da homeostasia energética. |
| title_full | O papel da leptina na regulação da homeostasia energética. |
| title_fullStr | O papel da leptina na regulação da homeostasia energética. |
| title_full_unstemmed | O papel da leptina na regulação da homeostasia energética. |
| title_short | O papel da leptina na regulação da homeostasia energética. |
| title_sort | o papel da leptina na regulacao da homeostasia energetica |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1694 |
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